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Spyre Therapeutics, Inc. SYRE Operating Cash Flow

Operating Cash Flow at other companies

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$1.1B-43.5%
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$5.33B+220%
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AbbVieABBV
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Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$7.67B+307%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities.

The official record: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s operating cash flow?
Spyre Therapeutics, Inc. (SYRE) reported operating cash flow of -$57.37M in Q1 2026.
How has Spyre Therapeutics, Inc.'s operating cash flow changed year-over-year?
Spyre Therapeutics, Inc.'s operating cash flow decreased by 40.0% year-over-year, from -$40.99M to -$57.37M.
What is the long-term trend for Spyre Therapeutics, Inc.'s operating cash flow?
Over 4 years (2021 to 2025), Spyre Therapeutics, Inc.'s operating cash flow has grown at a 32.0% compound annual growth rate (CAGR), from -$55.8M to -$169.25M.
What does operating cash flow mean?
The net cash flow resulting from the company's day-to-day business operations.
How do you interpret operating cash flow?
Higher values indicate a self-sustaining business model, while negative values indicate a reliance on external funding.
How does operating cash flow compare across companies?
Essential benchmark for all companies; negative in early-stage biotech, positive in mature firms.