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Spyre Therapeutics, Inc. SYRE Operating Cash Flow

Operating Cash Flow at other companies

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Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$9.2B+854%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities.

The source filing: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026.

Filed
May 5, 2026, 8:00 AM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001636282-26-000050
Line itemThree Months Ended March 31, 2026Three Months Ended March 31, 2025
Accrued and other liabilities3,653(5,998)
Related party accounts payable361,945
Prepaid expenses and other assets(233)462
Net cash used in operating activities(57,372)(40,994)
CASH FLOWS FROM INVESTING ACTIVITIES
Proceeds from maturities and sales of marketable securities107,74871,383
Purchases of marketable securities(81,167)(71,444)
Proceeds from sale of in-process research and development asset30,000

Item 1. Financial Statements (Unaudited).

FAQ

What is Spyre Therapeutics, Inc.'s operating cash flow?
Spyre Therapeutics, Inc. (SYRE) reported operating cash flow of -$57.37M in Q1 2026.
How has Spyre Therapeutics, Inc.'s operating cash flow changed year-over-year?
Spyre Therapeutics, Inc.'s operating cash flow decreased by 40.0% year-over-year, from -$40.99M to -$57.37M.
What is the long-term trend for Spyre Therapeutics, Inc.'s operating cash flow?
Over 4 years (2021 to 2025), Spyre Therapeutics, Inc.'s operating cash flow has grown at a 32.0% compound annual growth rate (CAGR), from -$55.8M to -$169.25M.
What does operating cash flow mean?
Total cash generated by or used in core business operations — the single most important cash flow metric for assessing business health.

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