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Operating margin at other companies

Johnson & Johnson logo
Johnson & JohnsonJNJ
26.4%+2.8pp
AbbVie logo
AbbVieABBV
24.4%
TG Therapeutics logo
TG TherapeuticsTGTX
21.3%+5.9pp
BridgeBio Pharma logo
BridgeBio PharmaBBIO
-90.5%-41.2pp
Summit Therapeutics logo
Summit TherapeuticsSMMT
-268,266.8%-272,316pp
Ionis Pharmaceuticals logo
Ionis PharmaceuticalsIONS
-33.3%-11.0pp

Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$7.67B+307%

Profitability

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Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Calculated from Spyre Therapeutics, Inc.’s reported figures.

Based on trailing twelve months.

The official record: Spyre Therapeutics, Inc.’s 10-Q, filed May 8, 2025, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s operating margin?
Spyre Therapeutics, Inc. (SYRE) reported operating margin of -39,428.9% in Q1 2024.
How has Spyre Therapeutics, Inc.'s operating margin changed year-over-year?
Spyre Therapeutics, Inc.'s operating margin decreased by 480.4% year-over-year, from -6,793.6% to -39,428.9%.
What is the long-term trend for Spyre Therapeutics, Inc.'s operating margin?
Over 2 years (2021 to 2023), Spyre Therapeutics, Inc.'s operating margin has grown at a 783.5% compound annual growth rate (CAGR), from -350.3% to -27,348%.
What does operating margin mean?
The profit left from core operations for every dollar of sales, before interest and taxes.
How do you interpret operating margin?
Expanding operating margin shows operating leverage — revenue growing faster than the cost base. Compression points to rising overhead, pricing pressure, or investment ahead of revenue.
How does operating margin compare across companies?
Strong cross-company signal within a sector. Capital-light businesses sustain higher operating margins than capital-intensive ones.