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Segments

By segment

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Reportable Segment-$69.01M-54.1%

Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$9.2B+854%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:NetIncomeLoss.

The source filing: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026.

Filed
May 5, 2026, 8:00 AM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001636282-26-000050
Line itemThree Months Ended March 31, 20262025
Total other (expense) income(23,364)8,779
Loss before income tax expense(69,005)(44,788)
Income tax benefit15
Net loss$(69,005)$(44,773)
Net loss per share, basic and diluted, Series A Preferred Stock$(29.66)$(23.95)
Weighted-average Series A non-voting convertible preferred stock outstanding, basic and diluted346,045346,045
Net loss per share, basic and diluted, Series B Preferred Stock$(29.66)$(23.95)
Weighted-average Series B non-voting convertible preferred stock outstanding, basic and diluted16,66716,667

Item 1. Financial Statements (Unaudited).

FAQ

What is Spyre Therapeutics, Inc.'s net income?
Spyre Therapeutics, Inc. (SYRE) reported net income of -$69.01M in Q1 2026.
How has Spyre Therapeutics, Inc.'s net income changed year-over-year?
Spyre Therapeutics, Inc.'s net income decreased by 54.1% year-over-year, from -$44.77M to -$69.01M.
What is the long-term trend for Spyre Therapeutics, Inc.'s net income?
Over 4 years (2021 to 2025), Spyre Therapeutics, Inc.'s net income has grown at a 23.9% compound annual growth rate (CAGR), from -$65.8M to -$155.2M.
What does net income mean?
The bottom line — total revenue minus all expenses, taxes, and costs. Represents the profit attributable to the company's shareholders after all obligations are met.

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