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Spyre Therapeutics, Inc. SYRE Business Segments — Net loss

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Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$7.67B+307%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:NetIncomeLoss.

The official record: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s business segments — net loss?
Spyre Therapeutics, Inc. (SYRE) reported business segments — net loss of -$69.01M in Q1 2026.
How has Spyre Therapeutics, Inc.'s business segments — net loss changed year-over-year?
Spyre Therapeutics, Inc.'s business segments — net loss decreased by 54.1% year-over-year, from -$44.77M to -$69.01M.
What is the long-term trend for Spyre Therapeutics, Inc.'s business segments — net loss?
Over 3 years (2022 to 2025), Spyre Therapeutics, Inc.'s business segments — net loss has grown at a 22.8% compound annual growth rate (CAGR), from -$83.82M to -$155.2M.
What does business segments — net loss mean?
The total loss generated by this business segment after all expenses.
How do you interpret business segments — net loss?
A narrowing loss suggests improved operational efficiency or a transition toward commercialization, while a widening loss reflects increased investment in development.
How does business segments — net loss compare across companies?
Standard metric for pre-revenue or clinical-stage biotech; compared against cash runway to assess financial health.