Skip to content
Screener

Spyre Therapeutics, Inc. SYRE Business Segments — Net loss

Similar metrics at other companies

Veradermics logo
MANEReportable Segment — Net loss
-$27.23M-120%
Zscaler logo
ZSReportable Segment — Net loss
-$13.88M-237%
Biohaven logo
BHVNReportable Segment — Net loss
-$130.53M+41.1%
Bicara Therapeutics logo
BCAXReportable Segment — Net loss
-$56.21M-52.6%
YSS
YSSReportable Segment — Net loss
-$114.84M-879%
Vaxcyte, Inc. logo
PCVXReportable Segment — Net loss
-$320.62M-128%

Other financials

Income statement

See full
Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

See full
Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

See full
Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

See full
Market cap$9.2B+854%

Profitability

See full
Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

See full
Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:NetIncomeLoss.

The source filing: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026.

Filed
May 5, 2026, 8:00 AM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001636282-26-000050
Line itemThree Months Ended March 31, 20262025
Total other (expense) income(23,364)8,779
Loss before income tax expense(69,005)(44,788)
Income tax benefit15
Net loss$(69,005)$(44,773)
Net loss per share, basic and diluted, Series A Preferred Stock$(29.66)$(23.95)
Weighted-average Series A non-voting convertible preferred stock outstanding, basic and diluted346,045346,045
Net loss per share, basic and diluted, Series B Preferred Stock$(29.66)$(23.95)
Weighted-average Series B non-voting convertible preferred stock outstanding, basic and diluted16,66716,667

Item 1. Financial Statements (Unaudited).

FAQ

What is Spyre Therapeutics, Inc.'s business segments — net loss?
Spyre Therapeutics, Inc. (SYRE) reported business segments — net loss of -$69.01M in Q1 2026.
How has Spyre Therapeutics, Inc.'s business segments — net loss changed year-over-year?
Spyre Therapeutics, Inc.'s business segments — net loss decreased by 54.1% year-over-year, from -$44.77M to -$69.01M.
What is the long-term trend for Spyre Therapeutics, Inc.'s business segments — net loss?
Over 3 years (2022 to 2025), Spyre Therapeutics, Inc.'s business segments — net loss has grown at a 22.8% compound annual growth rate (CAGR), from -$83.82M to -$155.2M.
What does business segments — net loss mean?
The bottom-line financial result for the segment, calculated as total segment revenue minus all associated operating expenses. For early-stage biotech, this represents the cash burn required to advance the therapeutic pipeline.

Ask your AI about Spyre Therapeutics, Inc.'s business segments — net loss.

Connect your AI assistant and compare it to peers, right in your chat.

Connect your AI
Harbor at dusk
Claude