What is Spyre Therapeutics, Inc.'s total revenue?

Spyre Therapeutics, Inc. (SYRE) reported total revenue of $0 in Q4 2025.

What is the long-term trend for Spyre Therapeutics, Inc.'s total revenue?

Over 4 years (2021 to 2025), Spyre Therapeutics, Inc.'s total revenue has grown at a -100.0% compound annual growth rate (CAGR), from $18.74M to $0.

What does total revenue mean?

The aggregate of all revenue from the company's operations — the top line from which all profitability metrics are derived.

Spyre Therapeutics, Inc. SYRE Total Revenue

Discontinued — last reported Q4 '25

Total Revenue at other companies

Bristol-Myers SquibbBMY

$11.49B+2.6%

Eli LillyLLY

$19.8B+55.5%

PfizerPFE

$14.45B+5.4%

Johnson & JohnsonJNJ

$24.06B+9.9%

Merck & Co.MRK

$16.29B+4.9%

AbbVieABBV

$15B+12.4%

Segments

By segment

See full

Reportable Segment$0—

Other financials

Income statement

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Operating income-$45.6M+14.8%

Net income-$69.0M-54.1%

EPS (diluted)-$0.74-23.3%

Balance sheet

See full

Cash & equivalents$97.2M+100%

Total debt$4.3M-9.6%

Total equity$670.8M+39.0%

Total assets$764.0M+34.1%

Cash flow

See full

Operating cash flow-$57.4M-40.0%

CapEx-—

Free cash flow-$39.4M-26.8%

Valuation

See full

Market cap$7.67B+307%

Profitability

See full

Operating margin-39,428.9%-49,795pp

Net margin-52,939.7%-61,871pp

FCF margin-3,442.8%-3,807pp

Returns & leverage

See full

Return on equity-31.1%-10.7pp

Debt / equity0.1×+0.1×

Current ratio9×+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax.

The official record: Spyre Therapeutics, Inc.’s 10-K, filed February 19, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s total revenue?: Spyre Therapeutics, Inc. (SYRE) reported total revenue of $0 in Q4 2025.
What is the long-term trend for Spyre Therapeutics, Inc.'s total revenue?: Over 4 years (2021 to 2025), Spyre Therapeutics, Inc.'s total revenue has grown at a -100.0% compound annual growth rate (CAGR), from $18.74M to $0.
What does total revenue mean?: The aggregate of all revenue from the company's operations — the top line from which all profitability metrics are derived.