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Spyre Therapeutics, Inc. SYRE Business Segments — Total Revenue

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Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$9.2B+854%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax.

The source filing: Spyre Therapeutics, Inc.’s 10-K, filed February 19, 2026.

Filed
Feb 19, 2026, 4:01 PM EST
Fiscal year
FY2025
Accession
0001636282-26-000020
Line itemYear Ended December 31, 2025Year Ended December 31, 2024Year Ended December 31, 2023
Revenue$886
Less:
Compensation$34,794$21,780$22,590
Stock-based compensation (1)37,61444,83325,675
Research and development, excluding compensation and stock-based compensation (2) (3)132,490127,49165,282
Other segment items (4) (5)(49,695)13,914226,129
Segment net loss$155,203$208,018$338,790
Reconciliation of net loss

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

FAQ

What is Spyre Therapeutics, Inc.'s business segments — total revenue?
Spyre Therapeutics, Inc. (SYRE) reported business segments — total revenue of $0 in Q4 2025.
What is the long-term trend for Spyre Therapeutics, Inc.'s business segments — total revenue?
Over 3 years (2022 to 2025), Spyre Therapeutics, Inc.'s business segments — total revenue has grown at a -100.0% compound annual growth rate (CAGR), from $2.33M to $0.
What does business segments — total revenue mean?
The total gross income generated by the segment from its primary business activities, such as licensing agreements, product sales, or research collaborations. It serves as the top-line indicator of the segment's market traction.

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