What is the long-term trend for Agios Pharmaceuticals's investments - gross unrealized losses?

Over 5 years (2020 to 2025), Agios Pharmaceuticals's investments - gross unrealized losses has grown at a -14.6% compound annual growth rate (CAGR), from $299M to $136.2M.

Agios Pharmaceuticals AGIO Investments - Gross Unrealized Losses

Investments - Gross Unrealized Losses at other companies

Vertex PharmaceuticalsVRTX

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BioCryst PharmaceuticalsBCRX

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Other financials

Income statement

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Revenue$20.7M+138%

Gross profit$19.4M+154%

Operating income-$110.0M-3.2%

Net income-$99.1M-11.0%

EPS (diluted)-$1.69-9.0%

Balance sheet

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Cash & equivalents$113.6M+43.9%

Total debt$35.7M-32.5%

Total equity$1.1B-24.4%

Total assets$1.2B-23.8%

Cash flow

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Operating cash flow-$118.9M-6.7%

CapEx$769.0K+0.4%

Free cash flow-$119.7M-6.6%

Valuation

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Market cap$2.16B+18.1%

Enterprise value$2.08B+15.2%

P/S32.7×-16.7×

Profitability

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Gross margin90%+2.5pp

Operating margin-720%-204pp

Net margin-639.8%—

FCF margin-582.5%-185pp

Returns & leverage

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Return on equity-32.8%—

Debt / equity0×0.0×

Current ratio14.2×-4.3×

Where this comes from

Reported directly by Agios Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:DebtSecuritiesAvailableForSaleUnrealizedLossPosition.

The official record: Agios Pharmaceuticals’s 10-Q, filed April 29, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Agios Pharmaceuticals's investments - gross unrealized losses?: Agios Pharmaceuticals (AGIO) reported investments - gross unrealized losses of $461.4M in Q1 2026.
How has Agios Pharmaceuticals's investments - gross unrealized losses changed year-over-year?: Agios Pharmaceuticals's investments - gross unrealized losses decreased by 21.4% year-over-year, from $586.9M to $461.4M.
What is the long-term trend for Agios Pharmaceuticals's investments - gross unrealized losses?: Over 5 years (2020 to 2025), Agios Pharmaceuticals's investments - gross unrealized losses has grown at a -14.6% compound annual growth rate (CAGR), from $299M to $136.2M.