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Other financials

Income statement

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Revenue$267.9M-40.7%
Gross profit$265.2M-40.8%
Operating income-$102.3M-173%
Net income-$114.6M-193%
EPS (diluted)-$0.69-199%

Balance sheet

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Cash & equivalents$350.1M+17.7%
Total debt$262.5M-67.0%
Total equity$439.7M-30.4%
Total assets$3.0B+0.3%

Cash flow

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Operating cash flow-$792.8M-426%
Free cash flow-$814.6M-399%

Valuation

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Market cap$9.01B+38.9%
Enterprise value$8.92B+27.7%
P/S10.3×+3.4×

Profitability

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Gross margin98.2%-0.7pp
Operating margin-68%-234pp
Net margin-64.7%-299pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-105.5%+336pp
Debt / equity0.6×-0.7×
Current ratio7.9×+5.0×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:PaymentsToAcquirePropertyPlantAndEquipment.

The source filing: Ionis Pharmaceuticals’s 10-Q, filed July 29, 2026.

Filed
Jul 29, 2026, 5:05 PM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0000874015-26-000251
Line itemSix Months Ended / June 30, 2026Six Months Ended / June 30, 2025
Investing activities:
Purchases of short-term investments(513,005)(802,657)
Proceeds from sale of short-term investments1,114,805880,545
Purchases of property, plant and equipment(37,843)(24,882)
Acquisition of licenses and other assets, net(3,640)(2,615)
Net cash provided by investing activities560,31750,391
Financing activities:
Proceeds from issuance of common stock through equity plans, net77,5603,528

ITEM 1. FINANCIAL STATEMENTS

FAQ

What is Ionis Pharmaceuticals's capex?
Ionis Pharmaceuticals (IONS) reported capex of $16.08M in Q2 2026.
How has Ionis Pharmaceuticals's capex changed year-over-year?
Ionis Pharmaceuticals's capex increased by 30.7% year-over-year, from $12.31M to $16.08M.
What is the long-term trend for Ionis Pharmaceuticals's capex?
Over 4 years (2021 to 2025), Ionis Pharmaceuticals's capex has grown at a 44.0% compound annual growth rate (CAGR), from $11.96M to $51.44M.
What does capex mean?
Cash spent on property, plant, and equipment — the primary measure of investment in productive capacity and infrastructure.

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