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Debt-to-equity at other companies

Eli Lilly logo
Eli LillyLLY
1.4×-1.1×
Pfizer logo
PfizerPFE
0.7×0.0×
Arrowhead Research logo
Arrowhead ResearchARWR
0.2×0.0×
ALN
Alnylam PharmaceuticalsALNY
0.2×-0.4×
Neurocrine Biosciences logo
Neurocrine BiosciencesNBIX
0.1×-0.1×
Roivant Sciences logo
Roivant SciencesROIV
0.0×

Other financials

Income statement

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Revenue$246.1M+87.0%
Gross profit$243.1M+86.8%
Operating income-$117.4M+20.0%
Net income-$92.5M+37.0%
EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%
Total debt$691.7M+334%
Total equity$491.4M+3.3%
Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$21.8M+73.0%
Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%
Enterprise value$12.77B+175%
P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp
Operating margin-33.3%-11.0pp
Net margin-30.9%-10.5pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-67.6%-20.3pp
Current ratio4.1×-5.6×

Where this comes from

Calculated from Ionis Pharmaceuticals’s reported figures.

Based on the most recent quarter.

The official record: Ionis Pharmaceuticals’s 10-Q, filed April 29, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's debt-to-equity?
Ionis Pharmaceuticals (IONS) reported debt-to-equity of 1.4× in Q1 2026.
How has Ionis Pharmaceuticals's debt-to-equity changed year-over-year?
Ionis Pharmaceuticals's debt-to-equity increased by 320.1% year-over-year, from 0.3× to 1.4×.
What is the long-term trend for Ionis Pharmaceuticals's debt-to-equity?
Over 5 years (2020 to 2025), Ionis Pharmaceuticals's debt-to-equity has grown at a 57.5% compound annual growth rate (CAGR), from 0.5× to 5×.
What does debt-to-equity mean?
How much debt the company carries for every dollar of shareholder equity.
How do you interpret debt-to-equity?
Lower is generally safer, but moderate leverage can boost returns. Read in the context of cash-flow stability — a utility tolerates more debt than a cyclical. Negative equity makes the ratio meaningless and it is suppressed there.
How does debt-to-equity compare across companies?
Comparable within an industry; capital structures differ sharply across sectors. Not meaningful for banks.