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Ionis Pharmaceuticals IONS Free cash flow margin

Free cash flow margin at other companies

Eli Lilly logo
Eli LillyLLY
16.4%+8.7pp
Pfizer logo
PfizerPFE
18%+8.8pp
Arrowhead Research logo
Arrowhead ResearchARWR
1.8%+0.9pp
ALN
Alnylam PharmaceuticalsALNY
15%+12.7pp
BridgeBio Pharma logo
BridgeBio PharmaBBIO
-76.8%
Neurocrine Biosciences logo
Neurocrine BiosciencesNBIX
26.8%+6.4pp

Other financials

Income statement

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Revenue$246.1M+87.0%
Gross profit$243.1M+86.8%
Operating income-$117.4M+20.0%
Net income-$92.5M+37.0%
EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%
Total debt$691.7M+334%
Total equity$491.4M+3.3%
Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$21.8M+73.0%
Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%
Enterprise value$12.77B+175%
P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp
Operating margin-33.3%-11.0pp
Net margin-30.9%-10.5pp

Returns & leverage

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Return on equity-67.6%-20.3pp
Debt / equity1.4×+1.1×
Current ratio4.1×-5.6×

Where this comes from

Calculated from Ionis Pharmaceuticals’s reported figures.

Based on trailing twelve months.

The official record: Ionis Pharmaceuticals’s 10-Q, filed April 29, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's free cash flow margin?
Ionis Pharmaceuticals (IONS) reported free cash flow margin of -77.4% in Q1 2025.
How has Ionis Pharmaceuticals's free cash flow margin changed year-over-year?
Ionis Pharmaceuticals's free cash flow margin decreased by 31.3% year-over-year, from -58.9% to -77.4%.
What is the long-term trend for Ionis Pharmaceuticals's free cash flow margin?
Over 4 years (2020 to 2024), Ionis Pharmaceuticals's free cash flow margin has grown at a 420.1% compound annual growth rate (CAGR), from 0.1% to -77.5%.
What does free cash flow margin mean?
How much real, spendable cash each sales dollar generates after reinvestment.
How do you interpret free cash flow margin?
A high and rising FCF margin is the hallmark of a cash-generative business. Persistent gaps between net margin and FCF margin warrant a look at working capital or capital intensity.
How does free cash flow margin compare across companies?
Strong cross-company quality signal; capital-light compounders post structurally higher FCF margins than asset-heavy peers.