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Return on equity at other companies

Eli Lilly logo
Eli LillyLLY
107.6%+29.9pp
Pfizer logo
PfizerPFE
10.6%
Arrowhead Research logo
Arrowhead ResearchARWR
-46.4%+341pp
ALN
Alnylam PharmaceuticalsALNY
66.9%
Neurocrine Biosciences logo
Neurocrine BiosciencesNBIX
22.5%+10.1pp
Roivant Sciences logo
Roivant SciencesROIV
-17.1%-17.7pp

Other financials

Income statement

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Revenue$246.1M+87.0%
Gross profit$243.1M+86.8%
Operating income-$117.4M+20.0%
Net income-$92.5M+37.0%
EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%
Total debt$691.7M+334%
Total equity$491.4M+3.3%
Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$21.8M+73.0%
Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%
Enterprise value$12.77B+175%
P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp
Operating margin-33.3%-11.0pp
Net margin-30.9%-10.5pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Debt / equity1.4×+1.1×
Current ratio4.1×-5.6×

Where this comes from

Calculated from Ionis Pharmaceuticals’s reported figures.

Based on trailing twelve months.

The official record: Ionis Pharmaceuticals’s 10-Q, filed April 29, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's return on equity?
Ionis Pharmaceuticals (IONS) reported return on equity of -67.6% in Q1 2026.
How has Ionis Pharmaceuticals's return on equity changed year-over-year?
Ionis Pharmaceuticals's return on equity increased by 43.0% year-over-year, from -118.6% to -67.6%.
What is the long-term trend for Ionis Pharmaceuticals's return on equity?
Over 5 years (2020 to 2025), Ionis Pharmaceuticals's return on equity has grown at a 12.0% compound annual growth rate (CAGR), from -40.1% to -70.8%.
What does return on equity mean?
How much profit the company earns on the money shareholders have invested.
How do you interpret return on equity?
Higher is better, but very high ROE can be manufactured by leverage — a thin equity base inflates the ratio. Read it next to debt-to-equity and ROIC to tell genuine returns from balance-sheet engineering.
How does return on equity compare across companies?
Comparable across peers, with the leverage caveat. Negative or near-zero equity makes ROE meaningless, so it is suppressed there.