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Ionis Pharmaceuticals IONS Operating Cash Flow

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Other financials

Income statement

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Revenue$267.9M-40.7%
Gross profit$265.2M-40.8%
Operating income-$102.3M-173%
Net income-$114.6M-193%
EPS (diluted)-$0.69-199%

Balance sheet

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Cash & equivalents$350.1M+17.7%
Total debt$262.5M-67.0%
Total equity$439.7M-30.4%
Total assets$3.0B+0.3%

Cash flow

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CapEx$16.1M+30.7%
Free cash flow-$814.6M-399%

Valuation

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Market cap$9.01B+38.9%
Enterprise value$8.92B+27.7%
P/S10.3×+3.4×

Profitability

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Gross margin98.2%-0.7pp
Operating margin-68%-234pp
Net margin-64.7%-299pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-105.5%+336pp
Debt / equity0.6×-0.7×
Current ratio7.9×+5.0×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities.

The source filing: Ionis Pharmaceuticals’s 10-Q, filed April 29, 2026.

Filed
Apr 29, 2026, 2:33 PM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0000874015-26-000177
Line itemThree Months Ended / March 31, 2026Three Months Ended / March 31, 2025
Accrued compensation(80,187)(43,039)
Accrued liabilities and other liabilities21,003333
Deferred contract revenue(20,818)(13,718)
Net cash used in operating activities(792,819)(150,775)
Investing activities:
Purchases of short-term investments(192,755)(311,068)
Proceeds from sale of short-term investments752,824494,755
Purchases of property, plant and equipment(21,763)(12,577)

ITEM 1. FINANCIAL STATEMENTS

FAQ

What is Ionis Pharmaceuticals's operating cash flow?
Ionis Pharmaceuticals (IONS) reported operating cash flow of -$792.82M in Q1 2026.
How has Ionis Pharmaceuticals's operating cash flow changed year-over-year?
Ionis Pharmaceuticals's operating cash flow decreased by 425.8% year-over-year, from -$150.78M to -$792.82M.
What is the long-term trend for Ionis Pharmaceuticals's operating cash flow?
Over 4 years (2021 to 2025), Ionis Pharmaceuticals's operating cash flow has grown at a 71.8% compound annual growth rate (CAGR), from $30.8M to -$268.58M.
What does operating cash flow mean?
Total cash generated by or used in core business operations — the single most important cash flow metric for assessing business health.

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