What is Prime Medicine's net change in cash?

Prime Medicine (PRME) reported net change in cash of $1.07M in Q1 2026.

How has Prime Medicine's net change in cash changed year-over-year?

Prime Medicine's net change in cash increased by 101.2% year-over-year, from -$90.6M to $1.07M.

What is the long-term trend for Prime Medicine's net change in cash?

Over 2 years (2021 to 2023), Prime Medicine's net change in cash has grown at a -4.9% compound annual growth rate (CAGR), from $161.57M to -$146.05M.

What does net change in cash mean?

Total increase or decrease in cash during the period — the sum of operating, investing, financing cash flows plus FX effects.

Prime Medicine PRME Net Change in Cash

Net Change in Cash at other companies

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-$1.99B-1,035%

Vertex PharmaceuticalsVRTX

$417.1M+268%

Intellia TherapeuticsNTLA

-$17.47M+68.0%

CRISPR TherapeuticsCRSP

$72.24M+215%

Beam TherapeuticsBEAM

-$6.64M-103%

RegenxbioRGNX

-$19.24M-127%

Other financials

Income statement

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Revenue$838.0K-61.6%

Operating income-$50.7M+3.3%

Net income-$49.1M+5.3%

EPS (diluted)-$0.28+30.0%

Balance sheet

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Cash & equivalents$77.8M-26.6%

Total debt$114.5M-5.5%

Total equity$76.7M-28.3%

Total assets$294.7M-10.2%

Cash flow

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Operating cash flow-$42.7M+12.6%

CapEx$214.0K-91.2%

Free cash flow-$42.9M+16.3%

Valuation

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Market cap$574.36M+111%

Enterprise value$611.08M+113%

P/S124×+6.3×

Profitability

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Operating margin-4,498.1%-1,134pp

Net margin-4,342.4%-1,099pp

FCF margin-3,607.4%—

Returns & leverage

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Return on equity-216.1%+1,519pp

Debt / equity1.5×+0.4×

Current ratio3.8×-1.0×

Where this comes from

Reported directly by Prime Medicine in its filing.

Tagged under the XBRL concept us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect.

The official record: Prime Medicine’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Prime Medicine's net change in cash?: Prime Medicine (PRME) reported net change in cash of $1.07M in Q1 2026.
How has Prime Medicine's net change in cash changed year-over-year?: Prime Medicine's net change in cash increased by 101.2% year-over-year, from -$90.6M to $1.07M.
What is the long-term trend for Prime Medicine's net change in cash?: Over 2 years (2021 to 2023), Prime Medicine's net change in cash has grown at a -4.9% compound annual growth rate (CAGR), from $161.57M to -$146.05M.
What does net change in cash mean?: Total increase or decrease in cash during the period — the sum of operating, investing, financing cash flows plus FX effects.