Where do Septerna, Inc.'s ratios come from?

Every ratio is computed from Septerna, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Septerna, Inc. SEPN Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Profitability
Operating margin	-77.1%+71.6pp	-148.6%+201pp	-349.2%+13,722pp	-14,071.1%-4,732pp	-9,339.1%-1,821pp
Net margin	-49.9%+56.5pp	-106.4%+160pp	-266.8%+11,786pp	-12,053%-3,949pp	-8,104.1%-1,425pp
Efficiency
Asset turnover	0.1×+0.1×	0.1×0.0×	0.1×—	——	——
Liquidity
Current ratio	4.7×0.0×	4.7×-1.8×	6.5×-15.6×	22.1×-10.1×	32.2×+4.4×
Leverage
Debt-to-equity	0.1×0.0×	0.1×0.0×	0.1×0.0×	0.1×—	——
Per Share
Book value per share	$8.46-2.0%	$8.63+1.2%	$8.52-0.3%	$8.55+194%	-$9.11-121%
Valuation
Market capitalization	$1.08B-13.6%	$1.25B+48.8%	$838.65M+75.7%	$477.22M+85.5%	$257.32M-74.7%
Price / sales	14.9×-12.2×	27.2×-10.9×	38×-619×	657.3×+394×	263.4×-683×
Price / book	2.9×-0.4×	3.3×+1.1×	2.2×+0.9×	1.3×—	——

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Where do Septerna, Inc.'s ratios come from?: Every ratio is computed from Septerna, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.