Upstream Bio, Inc. UPB Ratios & Valuation
| Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | ||
|---|---|---|---|---|---|---|
| Profitability | ||||||
| Operating margin | -5,176.5%-1,049pp | -5,618.8%-2,338pp | -5,020.1%-2,040pp | -4,464.6%-1,931pp | -4,127.4%— | |
| Net margin | -4,719%-1,270pp | -5,026%-2,376pp | -4,366.8%-1,947pp | -3,836.6%-2,013pp | -3,448.7%— | |
| Returns | ||||||
| Return on equity | -41.8%— | -35.4%— | —— | —— | —— | |
| Return on invested capital | -58.9%— | -83.2%— | —— | —— | —— | |
| Efficiency | ||||||
| Asset turnover | 0×— | 0×0.0× | 0×— | —— | —— | |
| Liquidity | ||||||
| Current ratio | 23.1×-24.3× | 26.2×-18.5× | 32.7×+11.8× | 38.3×— | 47.4×— | |
| Leverage | ||||||
| Debt-to-equity | 0×0.0× | 0×0.0× | 0×— | 0×— | 0×— | |
| Per Share | ||||||
| Book value per share | $5.60-32.7% | $6.31-81.6% | $7.02+113% | $7.60+116% | $8.31+119% | |
| Valuation | ||||||
| Market capitalization | $346.11M-40.9% | $1.47B+66.5% | $1.01B— | $612.71M— | $328.28M— | |
| Price / sales | 104.2×-151× | 514.1×+142× | 362.3×— | 225×— | 143×— | |
| Price / book | 1.1×-0.2× | 4.3×+2.4× | 2.7×— | 1.5×— | 0.7×— |
Chart any of these lines over time, or line them up against competitors.
Compare these in charts →Questions, answered.
- Where do Upstream Bio, Inc.'s ratios come from?
- Every ratio is computed from Upstream Bio, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.
