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Upstream Bio, Inc. UPB Return on invested capital

Return on invested capital at other companies

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AmgenAMGN
14.8%+3.6pp
Regeneron Pharmaceuticals logo
Regeneron PharmaceuticalsREGN
10.3%-1.5pp
Aclaris Therapeutics logo
Aclaris TherapeuticsACRS
-79.9%-22.6pp
Shattuck Labs, Inc. logo
Shattuck Labs, Inc.STTK
-69.7%-27.7pp
Savara logo
SavaraSVRA
-108.1%+10.8pp
AnaptysBio, Inc. logo
AnaptysBio, Inc.ANAB
-255.3%-510pp

Other financials

Income statement

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Revenue$773.0K-17.5%
Operating income-$42.4M+4.5%
Net income-$39.7M+0.7%
EPS (diluted)-$0.73+1.4%

Balance sheet

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Cash & equivalents$79.4M+74.7%
Total debt$954.0K-38.9%
Total equity$271.0M-33.7%
Total assets$281.2M-33.1%

Cash flow

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Operating cash flow-$35.6M+9.2%
CapEx$54.0K-70.8%
Free cash flow-$30.7M-55.0%

Valuation

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Market cap$394.54M-54.7%
Enterprise value$316.1M-61.6%
P/S124.9×-195×

Profitability

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Operating margin-5,382.6%+1,393pp
Net margin-4,955.7%+2,041pp

Returns & leverage

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Return on equity-46%
Debt / equity0.0×
Current ratio28×-10.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

Based on trailing twelve months.

The source filing: Upstream Bio, Inc.’s 10-Q, filed August 11, 2026. Open the filing →

Filed
Aug 11, 2026, 7:10 AM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0001193125-26-343417

FAQ

What is Upstream Bio, Inc.'s return on invested capital?
Upstream Bio, Inc. (UPB) reported return on invested capital of -61% in Q2 2026.
What does return on invested capital mean?
Net operating profit after tax (operating income taxed at the effective rate) divided by average invested capital (debt plus equity minus cash). Measures the after-tax return on all capital put to work in the business, independent of capital structure.

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