What is Upstream Bio, Inc.'s enterprise value?

Upstream Bio, Inc. (UPB) reported enterprise value of $394.17M in Q1 2026.

How has Upstream Bio, Inc.'s enterprise value changed year-over-year?

Upstream Bio, Inc.'s enterprise value increased by 52.4% year-over-year, from $258.67M to $394.17M.

What does enterprise value mean?

Market capitalization plus total debt minus cash, at the quarter end. The cost to acquire the whole business — what an buyer pays for equity and debt, net of the cash they'd inherit.

Upstream Bio, Inc. UPB Enterprise value

Enterprise value at other companies

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$246.43B+9.9%

Regeneron PharmaceuticalsREGN

$81.42B+18.1%

Aclaris TherapeuticsACRS

$427.4M+211%

Shattuck Labs, Inc.STTK

$372.63M+3,155%

SavaraSVRA

$1.11B+127%

AnaptysBio, Inc.ANAB

$1.35B+176%

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

See full

Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

$489.8Mmarket cap+$1.1Mtotal debt−$96.7Mcash and equivalents=$394.17M

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s enterprise value?: Upstream Bio, Inc. (UPB) reported enterprise value of $394.17M in Q1 2026.
How has Upstream Bio, Inc.'s enterprise value changed year-over-year?: Upstream Bio, Inc.'s enterprise value increased by 52.4% year-over-year, from $258.67M to $394.17M.
What does enterprise value mean?: Market capitalization plus total debt minus cash, at the quarter end. The cost to acquire the whole business — what an buyer pays for equity and debt, net of the cash they'd inherit.