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Upstream Bio, Inc. UPB Operating margin

Operating margin at other companies

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30%+6.5pp
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24.7%-2.3pp
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Aclaris TherapeuticsACRS
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-15,536.1%-17,275pp

Other financials

Income statement

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Revenue$773.0K-17.5%
Operating income-$42.4M+4.5%
Net income-$39.7M+0.7%
EPS (diluted)-$0.73+1.4%

Balance sheet

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Cash & equivalents$79.4M+74.7%
Total debt$954.0K-38.9%
Total equity$271.0M-33.7%
Total assets$281.2M-33.1%

Cash flow

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Operating cash flow-$35.6M+9.2%
CapEx$54.0K-70.8%
Free cash flow-$30.7M-55.0%

Valuation

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Market cap$394.54M-54.7%
Enterprise value$316.1M-61.6%
P/S124.9×-195×

Profitability

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Net margin-4,955.7%+2,041pp

Returns & leverage

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Return on equity-46%
Debt / equity0.0×
Current ratio28×-10.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

Based on trailing twelve months.

The source filing: Upstream Bio, Inc.’s 10-Q, filed August 11, 2026. Open the filing →

Filed
Aug 11, 2026, 7:10 AM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0001193125-26-343417

FAQ

What is Upstream Bio, Inc.'s operating margin?
Upstream Bio, Inc. (UPB) reported operating margin of -5,382.6% in Q2 2026.
How has Upstream Bio, Inc.'s operating margin changed year-over-year?
Upstream Bio, Inc.'s operating margin decreased by 20.6% year-over-year, from -4,464.6% to -5,382.6%.
What does operating margin mean?
Operating income as a percentage of revenue (trailing twelve months). Captures profitability from core operations after both cost of revenue and operating expenses, but before interest and taxes.

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