What is Upstream Bio, Inc.'s return on equity?

Upstream Bio, Inc. (UPB) reported return on equity of -41.8% in Q1 2026.

What does return on equity mean?

Trailing-twelve-month net income divided by average shareholders' equity (average of the start and end of the trailing-twelve-month window). Measures the profit generated on each dollar of shareholder capital.

Upstream Bio, Inc. UPB Return on equity

Return on equity at other companies

AmgenAMGN

101.3%-4.4pp

Regeneron PharmaceuticalsREGN

14.5%-1.4pp

Aclaris TherapeuticsACRS

-48.4%-15.4pp

Shattuck Labs, Inc.STTK

-61%-8.0pp

SavaraSVRA

-80%+4.7pp

AnaptysBio, Inc.ANAB

-343.8%-1,012pp

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

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Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

net income/total stockholders equity=-41.8%

Based on trailing twelve months.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s return on equity?: Upstream Bio, Inc. (UPB) reported return on equity of -41.8% in Q1 2026.
What does return on equity mean?: Trailing-twelve-month net income divided by average shareholders' equity (average of the start and end of the trailing-twelve-month window). Measures the profit generated on each dollar of shareholder capital.