What is Upstream Bio, Inc.'s capex?

Upstream Bio, Inc. (UPB) reported capex of $54K in Q4 2025.

How has Upstream Bio, Inc.'s capex changed year-over-year?

Upstream Bio, Inc.'s capex decreased by 70.8% year-over-year, from $185K to $54K.

What does capex mean?

Cash spent on property, plant, and equipment — the primary measure of investment in productive capacity and infrastructure.

Upstream Bio, Inc. UPB CapEx

Discontinued — last reported Q4 '25

CapEx at other companies

AmgenAMGN

$712M+73.2%

Regeneron PharmaceuticalsREGN

$230.6M+0.6%

Aclaris TherapeuticsACRS

$13K-69.8%

Shattuck Labs, Inc.STTK

$63K—

SavaraSVRA

$54K+1,700%

AnaptysBio, Inc.ANAB

$17K-51.4%

Other financials

Income statement

See full

Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

See full

Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

See full

Operating cash flow-$47.9M-16.2%

Free cash flow-$30.7M-55.0%

Valuation

See full

Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

See full

Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

See full

Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Reported directly by Upstream Bio, Inc. in its filing.

Tagged under the XBRL concept us-gaap:PaymentsToAcquirePropertyPlantAndEquipment.

The official record: Upstream Bio, Inc.’s 10-K, filed March 26, 2026, on SEC EDGAR. View the filing →

Ask your AI about Upstream Bio, Inc.'s capex.

Connect your AI assistant and compare it to peers, right in your chat.

Connect your AI

Claude

Questions, answered.

What is Upstream Bio, Inc.'s capex?: Upstream Bio, Inc. (UPB) reported capex of $54K in Q4 2025.
How has Upstream Bio, Inc.'s capex changed year-over-year?: Upstream Bio, Inc.'s capex decreased by 70.8% year-over-year, from $185K to $54K.
What does capex mean?: Cash spent on property, plant, and equipment — the primary measure of investment in productive capacity and infrastructure.