What is Upstream Bio, Inc.'s operating cash flow?

Upstream Bio, Inc. (UPB) reported operating cash flow of -$47.85M in Q1 2026.

How has Upstream Bio, Inc.'s operating cash flow changed year-over-year?

Upstream Bio, Inc.'s operating cash flow decreased by 16.2% year-over-year, from -$41.17M to -$47.85M.

What does operating cash flow mean?

Total cash generated by or used in core business operations — the single most important cash flow metric for assessing business health.

Upstream Bio, Inc. UPB Operating Cash Flow

Operating Cash Flow at other companies

AmgenAMGN

$2.19B+57.4%

Regeneron PharmaceuticalsREGN

$1.08B+3.2%

Aclaris TherapeuticsACRS

-$18.15M-39.0%

Shattuck Labs, Inc.STTK

-$13.42M-11.6%

SavaraSVRA

-$33.05M-21.5%

AnaptysBio, Inc.ANAB

-$25.92M-142%

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

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Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Reported directly by Upstream Bio, Inc. in its filing.

Tagged under the XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s operating cash flow?: Upstream Bio, Inc. (UPB) reported operating cash flow of -$47.85M in Q1 2026.
How has Upstream Bio, Inc.'s operating cash flow changed year-over-year?: Upstream Bio, Inc.'s operating cash flow decreased by 16.2% year-over-year, from -$41.17M to -$47.85M.
What does operating cash flow mean?: Total cash generated by or used in core business operations — the single most important cash flow metric for assessing business health.