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Upstream Bio, Inc. UPB Operating Cash Flow

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Other financials

Income statement

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Revenue$773.0K-17.5%
Operating income-$42.4M+4.5%
Net income-$39.7M+0.7%
EPS (diluted)-$0.73+1.4%

Balance sheet

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Cash & equivalents$79.4M+74.7%
Total debt$954.0K-38.9%
Total equity$271.0M-33.7%
Total assets$281.2M-33.1%

Cash flow

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CapEx$54.0K-70.8%
Free cash flow-$30.7M-55.0%

Valuation

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Market cap$394.54M-54.7%
Enterprise value$316.1M-61.6%
P/S124.9×-195×

Profitability

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Operating margin-5,382.6%+1,393pp
Net margin-4,955.7%+2,041pp

Returns & leverage

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Return on equity-46%
Debt / equity0.0×
Current ratio28×-10.3×

Where this comes from

Reported directly by Upstream Bio, Inc. in its filing.

Tagged under the XBRL concept us-gaap:NetCashProvidedByUsedInOperatingActivities.

The source filing: Upstream Bio, Inc.’s 10-Q, filed August 11, 2026.

Filed
Aug 11, 2026, 7:10 AM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0001193125-26-343417
Line itemSix Months Ended June 30, 2026Six Months Ended June 30, 2025
Accounts payable(412)(1,456)
Accrued expenses and other current liabilities(3,060)1,674
Operating lease liabilities(315)(273)
Net cash used in operating activities(83,473)(80,404)
Cash flows from investing activities:
Purchases of short-term investments(65,363)(323,138)
Maturities of short-term investments123,524122,577
Purchases of equipment(47)

Item 1. Financial Statements.

FAQ

What is Upstream Bio, Inc.'s operating cash flow?
Upstream Bio, Inc. (UPB) reported operating cash flow of -$35.62M in Q2 2026.
How has Upstream Bio, Inc.'s operating cash flow changed year-over-year?
Upstream Bio, Inc.'s operating cash flow increased by 9.2% year-over-year, from -$39.24M to -$35.62M.
What does operating cash flow mean?
Total cash generated by or used in core business operations — the single most important cash flow metric for assessing business health.

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