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Upstream Bio, Inc. UPB Operating Income

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Other financials

Income statement

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Revenue$773.0K-17.5%
Net income-$39.7M+0.7%
EPS (diluted)-$0.73+1.4%

Balance sheet

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Cash & equivalents$79.4M+74.7%
Total debt$954.0K-38.9%
Total equity$271.0M-33.7%
Total assets$281.2M-33.1%

Cash flow

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Operating cash flow-$35.6M+9.2%
CapEx$54.0K-70.8%
Free cash flow-$30.7M-55.0%

Valuation

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Market cap$394.54M-54.7%
Enterprise value$316.1M-61.6%
P/S124.9×-195×

Profitability

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Operating margin-5,382.6%+1,393pp
Net margin-4,955.7%+2,041pp

Returns & leverage

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Return on equity-46%
Debt / equity0.0×
Current ratio28×-10.3×

Where this comes from

Reported directly by Upstream Bio, Inc. in its filing.

Tagged under the XBRL concept us-gaap:OperatingIncomeLoss.

The source filing: Upstream Bio, Inc.’s 10-Q, filed August 11, 2026.

Filed
Aug 11, 2026, 7:10 AM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0001193125-26-343417
Line itemThree Months Ended June 30, 2026Three Months Ended June 30, 2025Six Months Ended June 30, 2026Six Months Ended June 30, 2025
Research and development36,08937,86572,65463,662
General and administrative7,0527,41915,13614,201
Total operating expenses43,14145,28487,79077,863
Loss from operations(42,368)(44,347)(85,983)(76,360)
Other income (expense):
Interest income2,6594,4315,7139,174
Other income (expense), net7(50)(23)(50)
Total other income, net2,6664,3815,6909,124

Item 1. Financial Statements.

FAQ

What is Upstream Bio, Inc.'s operating income?
Upstream Bio, Inc. (UPB) reported operating income of -$42.37M in Q2 2026.
How has Upstream Bio, Inc.'s operating income changed year-over-year?
Upstream Bio, Inc.'s operating income increased by 4.5% year-over-year, from -$44.35M to -$42.37M.
What does operating income mean?
Gross profit minus all operating expenses (SG&A, R&D, D&A). Measures the profit from core business operations before interest, taxes, and non-operating items.

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