What is Upstream Bio, Inc.'s operating income?

Upstream Bio, Inc. (UPB) reported operating income of -$43.62M in Q1 2026.

How has Upstream Bio, Inc.'s operating income changed year-over-year?

Upstream Bio, Inc.'s operating income decreased by 36.2% year-over-year, from -$32.01M to -$43.62M.

What does operating income mean?

Gross profit minus all operating expenses (SG&A, R&D, D&A). Measures the profit from core business operations before interest, taxes, and non-operating items.

Upstream Bio, Inc. UPB Operating Income

Operating Income at other companies

AmgenAMGN

$2.67B+126%

Regeneron PharmaceuticalsREGN

$642.9M+8.7%

Aclaris TherapeuticsACRS

-$22.19M-22.7%

Shattuck Labs, Inc.STTK

-$15.55M-8.0%

SavaraSVRA

-$38.99M-37.1%

AnaptysBio, Inc.ANAB

-$34.64M-25.8%

Other financials

Income statement

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Revenue$1.0M+82.7%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

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Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Reported directly by Upstream Bio, Inc. in its filing.

Tagged under the XBRL concept us-gaap:OperatingIncomeLoss.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s operating income?: Upstream Bio, Inc. (UPB) reported operating income of -$43.62M in Q1 2026.
How has Upstream Bio, Inc.'s operating income changed year-over-year?: Upstream Bio, Inc.'s operating income decreased by 36.2% year-over-year, from -$32.01M to -$43.62M.
What does operating income mean?: Gross profit minus all operating expenses (SG&A, R&D, D&A). Measures the profit from core business operations before interest, taxes, and non-operating items.