What is Upstream Bio, Inc.'s debt-to-equity?

Upstream Bio, Inc. (UPB) reported debt-to-equity of 0× in Q1 2026.

How has Upstream Bio, Inc.'s debt-to-equity changed year-over-year?

Upstream Bio, Inc.'s debt-to-equity decreased by 2.6% year-over-year, from 0× to 0×.

What does debt-to-equity mean?

Total debt (including capitalized leases and financing obligations) divided by shareholders' equity at the quarter end. Measures how much the company is financed by debt relative to equity.

Upstream Bio, Inc. UPB Debt-to-equity

Debt-to-equity at other companies

AmgenAMGN

6.2×-3.0×

Regeneron PharmaceuticalsREGN

0.1×0.0×

Aclaris TherapeuticsACRS

0×0.0×

Shattuck Labs, Inc.STTK

0×0.0×

SavaraSVRA

0.2×0.0×

AnaptysBio, Inc.ANAB

0×-0.5×

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

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Return on equity-41.8%—

Current ratio23.1×-24.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

total debt/total stockholders equity=0×

Based on the most recent quarter.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s debt-to-equity?: Upstream Bio, Inc. (UPB) reported debt-to-equity of 0× in Q1 2026.
How has Upstream Bio, Inc.'s debt-to-equity changed year-over-year?: Upstream Bio, Inc.'s debt-to-equity decreased by 2.6% year-over-year, from 0× to 0×.
What does debt-to-equity mean?: Total debt (including capitalized leases and financing obligations) divided by shareholders' equity at the quarter end. Measures how much the company is financed by debt relative to equity.