What is Upstream Bio, Inc.'s price / book?

Upstream Bio, Inc. (UPB) reported price / book of 1.6× in Q1 2026.

How has Upstream Bio, Inc.'s price / book changed year-over-year?

Upstream Bio, Inc.'s price / book increased by 118.7% year-over-year, from 0.7× to 1.6×.

What does price / book mean?

Market capitalization at the quarter end divided by shareholders' equity. The premium (or discount) the market assigns to the company's book equity.

Upstream Bio, Inc. UPB Price / book

Price / book at other companies

AmgenAMGN

20.6×-6.3×

Regeneron PharmaceuticalsREGN

2.6×+0.2×

Aclaris TherapeuticsACRS

3.2×+2.0×

Shattuck Labs, Inc.STTK

4.8×+4.1×

SavaraSVRA

6.3×+3.1×

AnaptysBio, Inc.ANAB

125.1×+108×

Other financials

Income statement

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Revenue$1.0M+82.7%

Operating income-$43.6M-36.2%

Net income-$40.6M-48.8%

EPS (diluted)-$0.75-47.1%

Balance sheet

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Cash & equivalents$96.7M+35.6%

Total debt$1.1M-34.5%

Total equity$304.0M-31.8%

Total assets$318.1M-30.3%

Cash flow

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Operating cash flow-$47.9M-16.2%

CapEx$54.0K-70.8%

Free cash flow-$30.7M-55.0%

Valuation

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Market cap$346.11M-40.9%

Enterprise value$250.5M-51.4%

P/S104.2×-151×

Profitability

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Operating margin-5,176.5%+1,764pp

Net margin-4,719%+2,752pp

Returns & leverage

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Return on equity-41.8%—

Debt / equity0×0.0×

Current ratio23.1×-24.3×

Where this comes from

Calculated from Upstream Bio, Inc.’s reported figures.

market cap/total stockholders equity=1.6×

Based on the most recent quarter.

The official record: Upstream Bio, Inc.’s 10-Q, filed May 13, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Upstream Bio, Inc.'s price / book?: Upstream Bio, Inc. (UPB) reported price / book of 1.6× in Q1 2026.
How has Upstream Bio, Inc.'s price / book changed year-over-year?: Upstream Bio, Inc.'s price / book increased by 118.7% year-over-year, from 0.7× to 1.6×.
What does price / book mean?: Market capitalization at the quarter end divided by shareholders' equity. The premium (or discount) the market assigns to the company's book equity.