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EBITDA margin at other companies

Eli Lilly logo
Eli LillyLLY
45.9%+14.4pp
Pfizer logo
PfizerPFE
25.3%
Arrowhead Research logo
Arrowhead ResearchARWR
-31.6%+105pp
ALN
Alnylam PharmaceuticalsALNY
18.8%+16.9pp
BridgeBio Pharma logo
BridgeBio PharmaBBIO
-89.6%-40.8pp
Neurocrine Biosciences logo
Neurocrine BiosciencesNBIX
26.4%+4.7pp

Other financials

Income statement

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Revenue$246.1M+87.0%
Gross profit$243.1M+86.8%
Operating income-$117.4M+20.0%
Net income-$92.5M+37.0%
EPS (diluted)-$0.56+39.8%

Balance sheet

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Cash & equivalents$173.4M-34.4%
Total debt$691.7M+334%
Total equity$491.4M+3.3%
Total assets$3.4B+22.6%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$21.8M+73.0%
Free cash flow-$814.6M-399%

Valuation

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Market cap$12.25B+159%
Enterprise value$12.77B+175%
P/S11.6×+5.0×

Profitability

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Gross margin98.4%-0.2pp
Operating margin-33.3%-11.0pp
Net margin-30.9%-10.5pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-67.6%-20.3pp
Debt / equity1.4×+1.1×
Current ratio4.1×-5.6×

Where this comes from

Calculated from Ionis Pharmaceuticals’s reported figures.

Based on trailing twelve months.

The official record: Ionis Pharmaceuticals’s 10-Q, filed April 29, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Ionis Pharmaceuticals's EBITDA margin?
Ionis Pharmaceuticals (IONS) reported EBITDA margin of -32% in Q1 2026.
How has Ionis Pharmaceuticals's EBITDA margin changed year-over-year?
Ionis Pharmaceuticals's EBITDA margin increased by 50.2% year-over-year, from -64.3% to -32%.
What is the long-term trend for Ionis Pharmaceuticals's EBITDA margin?
Over 5 years (2020 to 2025), Ionis Pharmaceuticals's EBITDA margin has grown at a 12.7% compound annual growth rate (CAGR), from -21.5% to -39.1%.
What does EBITDA margin mean?
Operating cash profitability per sales dollar, before interest, taxes, and non-cash charges.
How do you interpret EBITDA margin?
Useful for comparing operating profitability across firms with different depreciation policies and leverage. High EBITDA margin alongside heavy capex can still mean weak free cash flow — pair it with FCF margin.
How does EBITDA margin compare across companies?
Widely used to compare capital-intensive businesses on a like-for-like basis. Less meaningful for banks and insurers.