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Other financials

Income statement

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Revenue$267.9M-40.7%
Gross profit$265.2M-40.8%
Operating income-$102.3M-173%
Net income-$114.6M-193%
EPS (diluted)-$0.69-199%

Balance sheet

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Cash & equivalents$350.1M+17.7%
Total debt$262.5M-67.0%
Total equity$439.7M-30.4%
Total assets$3.0B+0.3%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$16.1M+30.7%
Free cash flow-$814.6M-399%

Valuation

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Market cap$9.01B+38.9%
Enterprise value$8.92B+27.7%
P/S10.3×+3.4×

Profitability

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Gross margin98.2%-0.7pp
Operating margin-68%-234pp
Net margin-64.7%-299pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-105.5%+336pp
Debt / equity0.6×-0.7×
Current ratio7.9×+5.0×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:InvestmentIncomeNet.

The source filing: Ionis Pharmaceuticals’s 10-Q, filed July 29, 2026.

Filed
Jul 29, 2026, 5:05 PM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0000874015-26-000251
Line itemThree Months Ended / June 30, 2026Three Months Ended / June 30, 2025Six Months Ended / June 30, 2026Six Months Ended / June 30, 2025
Total operating expenses370,242312,233733,756590,705
Income (loss) from operations(102,293)139,816(219,714)(7,045)
Other income (expense):
Investment income20,23024,68745,71349,354
Interest expense(4,618)(4,114)(9,778)(8,223)
Interest expense related to sale of future royalties(17,506)(18,648)(34,843)(37,470)
Gain (loss) on investments, net(10,182)(18,312)12,401(20,476)
Other income, net987102529569

ITEM 1. FINANCIAL STATEMENTS

FAQ

What is Ionis Pharmaceuticals's interest income?
Ionis Pharmaceuticals (IONS) reported interest income of $20.23M in Q2 2026.
How has Ionis Pharmaceuticals's interest income changed year-over-year?
Ionis Pharmaceuticals's interest income decreased by 18.1% year-over-year, from $24.69M to $20.23M.
What is the long-term trend for Ionis Pharmaceuticals's interest income?
Over 4 years (2021 to 2025), Ionis Pharmaceuticals's interest income has grown at a 76.6% compound annual growth rate (CAGR), from $10.06M to $97.77M.
What does interest income mean?
Income earned from interest-bearing assets including cash deposits, money market funds, treasury securities, corporate bonds, and customer financing receivables.

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