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Ionis Pharmaceuticals IONS Net Change in Cash

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Other financials

Income statement

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Revenue$267.9M-40.7%
Gross profit$265.2M-40.8%
Operating income-$102.3M-173%
Net income-$114.6M-193%
EPS (diluted)-$0.69-199%

Balance sheet

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Cash & equivalents$350.1M+17.7%
Total debt$262.5M-67.0%
Total equity$439.7M-30.4%
Total assets$3.0B+0.3%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$16.1M+30.7%
Free cash flow-$814.6M-399%

Valuation

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Market cap$9.01B+38.9%
Enterprise value$8.92B+27.7%
P/S10.3×+3.4×

Profitability

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Gross margin98.2%-0.7pp
Operating margin-68%-234pp
Net margin-64.7%-299pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-105.5%+336pp
Debt / equity0.6×-0.7×
Current ratio7.9×+5.0×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect.

The source filing: Ionis Pharmaceuticals’s 10-Q, filed April 29, 2026.

Filed
Apr 29, 2026, 2:33 PM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0000874015-26-000177
Line itemThree Months Ended / March 31, 2026Three Months Ended / March 31, 2025
Principal payments on mortgage debt(44)(42)
Net cash provided by financing activities57,2582,199
Effects of exchange rates on cash(138)232
Net increase (decrease) in cash and cash equivalents(198,879)22,115
Cash and cash equivalents at beginning of period372,260242,077
Cash and cash equivalents at end of period$$173,381264,192
Supplemental disclosures of cash flow information:
Interest paid$$9092

ITEM 1. FINANCIAL STATEMENTS

FAQ

What is Ionis Pharmaceuticals's net change in cash?
Ionis Pharmaceuticals (IONS) reported net change in cash of -$198.88M in Q1 2026.
How has Ionis Pharmaceuticals's net change in cash changed year-over-year?
Ionis Pharmaceuticals's net change in cash decreased by 999.3% year-over-year, from $22.12M to -$198.88M.
What is the long-term trend for Ionis Pharmaceuticals's net change in cash?
Over 3 years (2021 to 2025), Ionis Pharmaceuticals's net change in cash has grown at a -34.9% compound annual growth rate (CAGR), from $471.53M to $130.18M.
What does net change in cash mean?
Total increase or decrease in cash during the period — the sum of operating, investing, financing cash flows plus FX effects.

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