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Ionis Pharmaceuticals IONS Net Operating Loss Carryforwards

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Other financials

Income statement

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Revenue$267.9M-40.7%
Gross profit$265.2M-40.8%
Operating income-$102.3M-173%
Net income-$114.6M-193%
EPS (diluted)-$0.69-199%

Balance sheet

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Cash & equivalents$350.1M+17.7%
Total debt$262.5M-67.0%
Total equity$439.7M-30.4%
Total assets$3.0B+0.3%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$16.1M+30.7%
Free cash flow-$814.6M-399%

Valuation

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Market cap$9.01B+38.9%
Enterprise value$8.92B+27.7%
P/S10.3×+3.4×

Profitability

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Gross margin98.2%-0.7pp
Operating margin-68%-234pp
Net margin-64.7%-299pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-105.5%+336pp
Debt / equity0.6×-0.7×
Current ratio7.9×+5.0×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:DeferredTaxAssetsTaxCreditCarryforwards.

The source filing: Ionis Pharmaceuticals’s 10-K, filed February 26, 2026.

Filed
Feb 26, 2026, 4:25 PM EST
Fiscal year
FY2026
Accession
0000874015-26-000115
Line itemYear Ended December 31, 2025Year Ended December 31, 2024
Deferred Tax Assets:
Net operating loss carryovers$$290,85195,851
Tax credits361,056310,703
Deferred revenue38,83054,063
Stock-based compensation67,58582,660
Intangible and capital assets76,28393,541
Convertible debt1,3059,310
Capitalized research and development expenses233,485323,560

Item 15. Exhibits and Financial Statement Schedules

FAQ

What is Ionis Pharmaceuticals's net operating loss carryforwards?
Ionis Pharmaceuticals (IONS) reported net operating loss carryforwards of $361.06M in Q4 2025.
What does net operating loss carryforwards mean?
These are tax assets representing losses that can be used to reduce taxable income in future periods. They provide a potential future tax shield, improving cash flow by lowering future tax payments. Investors monitor these to estimate the duration and magnitude of potential tax savings.

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