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Ionis Pharmaceuticals IONS Retained Earnings

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Other financials

Income statement

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Revenue$267.9M-40.7%
Gross profit$265.2M-40.8%
Operating income-$102.3M-173%
Net income-$114.6M-193%
EPS (diluted)-$0.69-199%

Balance sheet

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Cash & equivalents$350.1M+17.7%
Total debt$262.5M-67.0%
Total equity$439.7M-30.4%
Total assets$3.0B+0.3%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$16.1M+30.7%
Free cash flow-$814.6M-399%

Valuation

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Market cap$9.01B+38.9%
Enterprise value$8.92B+27.7%
P/S10.3×+3.4×

Profitability

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Gross margin98.2%-0.7pp
Operating margin-68%-234pp
Net margin-64.7%-299pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-105.5%+336pp
Debt / equity0.6×-0.7×
Current ratio7.9×+5.0×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:RetainedEarningsAccumulatedDeficit.

The source filing: Ionis Pharmaceuticals’s 10-Q, filed July 29, 2026.

Filed
Jul 29, 2026, 5:05 PM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0000874015-26-000251
Line itemJune 30, 2026December 31, 2025
Total liabilities2,554,7643,034,747
Stockholders’ equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 165,636,792 and 163,304,875 shares issued and outstanding at June 30, 2026 and December 31, 2025, respectively166163
Additional paid-in capital3,311,8373,145,402
Accumulated other comprehensive loss(33,897)(25,281)
Accumulated deficit(2,838,369)(2,631,195)
Total stockholders' equity439,737489,089
Total liabilities and stockholders’ equity$$2,994,5013,523,836

ITEM 1. FINANCIAL STATEMENTS

FAQ

What is Ionis Pharmaceuticals's retained earnings?
Ionis Pharmaceuticals (IONS) reported retained earnings of -$2.84B in Q2 2026.
How has Ionis Pharmaceuticals's retained earnings changed year-over-year?
Ionis Pharmaceuticals's retained earnings decreased by 24.9% year-over-year, from -$2.27B to -$2.84B.
What is the long-term trend for Ionis Pharmaceuticals's retained earnings?
Over 5 years (2020 to 2025), Ionis Pharmaceuticals's retained earnings has grown at a 16.1% compound annual growth rate (CAGR), from -$1.25B to -$2.63B.
What does retained earnings mean?
Cumulative net income earned since inception minus all dividends paid — the total profits reinvested in the business over its lifetime.

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