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Ionis Pharmaceuticals IONS Unrealized Gains on Investments

Unrealized Gains on Investments at other companies

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Other financials

Income statement

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Revenue$267.9M-40.7%
Gross profit$265.2M-40.8%
Operating income-$102.3M-173%
Net income-$114.6M-193%
EPS (diluted)-$0.69-199%

Balance sheet

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Cash & equivalents$350.1M+17.7%
Total debt$262.5M-67.0%
Total equity$439.7M-30.4%
Total assets$3.0B+0.3%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$16.1M+30.7%
Free cash flow-$814.6M-399%

Valuation

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Market cap$9.46B+45.4%
Enterprise value$9.37B+33.8%
P/S10.8×+3.9×

Profitability

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Gross margin98.2%-0.7pp
Operating margin-68%-234pp
Net margin-64.7%-299pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-105.5%+336pp
Debt / equity0.6×-0.7×
Current ratio7.9×+5.0×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax.

The source filing: Ionis Pharmaceuticals’s 10-Q, filed July 29, 2026.

Filed
Jul 29, 2026, 5:05 PM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0000874015-26-000251
June 30, 2026Amortized / CostGross Unrealized / GainsGross Unrealized / LossesEstimated / Fair Value
Debt securities issued by the U.S. Treasury181,168-(1,340)179,828
Debt securities issued by states of the U.S. and political subdivisions of the states731-(1)730
Total debt securities with a maturity of more than one year651,14591(3,911)647,325
Total available-for-sale debt securities$$1,788,862$516$(5,012)1,784,366
Equity securities:
Publicly traded equity securities included in other current assets (2)$$11,897$45,670$(9,799)47,768
Privately held equity securities included in deposits and other assets (3)10,0009,816-19,816
Total equity securities21,89755,486(9,799)67,584

ITEM 1. FINANCIAL STATEMENTS

FAQ

What is Ionis Pharmaceuticals's unrealized gains on investments?
Ionis Pharmaceuticals (IONS) reported unrealized gains on investments of $516K in Q2 2026.
How has Ionis Pharmaceuticals's unrealized gains on investments changed year-over-year?
Ionis Pharmaceuticals's unrealized gains on investments decreased by 79.4% year-over-year, from $2.51M to $516K.
What is the long-term trend for Ionis Pharmaceuticals's unrealized gains on investments?
Over 4 years (2021 to 2025), Ionis Pharmaceuticals's unrealized gains on investments has grown at a 35.2% compound annual growth rate (CAGR), from $1.26M to $4.22M.
What does unrealized gains on investments mean?
This reflects the cumulative positive difference between the current fair market value and the carrying value of available-for-sale debt securities. These gains are typically recorded in accumulated other comprehensive income rather than the income statement. It indicates the potential upside value embedded within the company's treasury investment portfolio.

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