Skip to content
Q1 '26Q4 '25Q3 '25Q2 '25Q1 '25
$60.41M+35.3%$44.64M-1.3%$45.25M+12.7%$40.15M-3.6%$41.62M-17.5%
$15.23M+21.5%$12.53M+7.7%$11.64M-1.3%$11.79M-1.3%$11.94M+10.9%
$45.64M-20.2%$57.17M+0.5%$56.89M+35.7%$41.94M-21.7%$53.57M-12.5%
-$45.64M+20.2%-$57.17M-0.5%-$56.89M-35.7%-$41.94M+21.7%-$53.57M+12.5%
-$23.36M$0-100%$45.71M+776%$5.22M-40.6%$8.78M+77.1%
-$69.01M-10.4%-$62.53M-459%-$11.18M+69.5%-$36.72M+18.0%-$44.79M+20.4%
$0$0$0$0+100%-$15K-1,600%
-$69.01M-10.4%-$62.53M-459%-$11.18M+69.5%-$36.72M+18.0%-$44.77M+20.5%
-$0.740.0%-$0.74-393%-$0.15+69.4%-$0.49+18.3%-$0.60-150%
-$45.64M+20.2%-$57.17M-0.5%-$56.89M-35.7%-$41.94M+21.7%-$53.57M+12.5%

Chart any of these lines over time, or line them up against competitors.

Compare these in charts →

Questions, answered.

Is Spyre Therapeutics, Inc. profitable?
Spyre Therapeutics, Inc. is not currently profitable: it reported a net loss of $179.4M over the trailing twelve months, a -52939.7% net margin.
What is Spyre Therapeutics, Inc.'s earnings per share?
Spyre Therapeutics, Inc.'s diluted EPS over the trailing twelve months is $-2.12.
Where does Spyre Therapeutics, Inc.'s income statement data come from?
Every line is extracted from Spyre Therapeutics, Inc.'s SEC filings (10-K and 10-Q) and tagged in XBRL. Switch between quarterly, annual, and trailing-twelve-month views, or open any line for its full history and peer comparisons.