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Segments

By segment

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Reportable Segment$46.89M+39.8%

Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$9.12B+846%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Reported directly by Spyre Therapeutics, Inc. in its filing.

Tagged under the XBRL concept us-gaap:ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost.

The source filing: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026.

Filed
May 5, 2026, 8:00 AM EDT
Fiscal quarter
Q1 FY2026
Calendar quarter
Q1 2026
Accession
0001636282-26-000050
Line itemThree Months Ended March 31, 20262025
Operating expenses:
Research and development (1)60,41141,623
General and administrative (2)15,23011,944
Gain on sale of in-process research and development asset(30,000)
Total operating expenses45,64153,567
Loss from operations(45,641)(53,567)
Other (expense) income:
Interest income6,9956,493

Item 1. Financial Statements (Unaudited).

FAQ

What is Spyre Therapeutics, Inc.'s R&D?
Spyre Therapeutics, Inc. (SYRE) reported R&D of $60.41M in Q1 2026.
How has Spyre Therapeutics, Inc.'s R&D changed year-over-year?
Spyre Therapeutics, Inc.'s R&D increased by 45.1% year-over-year, from $41.62M to $60.41M.
What is the long-term trend for Spyre Therapeutics, Inc.'s R&D?
Over 4 years (2021 to 2025), Spyre Therapeutics, Inc.'s R&D has grown at a 31.7% compound annual growth rate (CAGR), from $57.07M to $171.65M.
What does R&D mean?
Costs of research activities to discover new knowledge and development activities to translate research into new or improved products, services, processes, or technologies.

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