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TTM Q1 '26TTM Q4 '25TTM Q3 '25TTM Q2 '25TTM Q1 '25
$190.44M+10.9%$171.65M-3.3%$177.5M+0.3%$176.99M+4.4%$169.49M+4.1%
$51.2M+6.9%$47.91M+3.8%$46.15M+2.2%$45.15M+0.6%$44.87M-2.0%
$201.64M-3.8%$209.56M-1.9%$213.64M+0.7%$212.15M-1.0%$214.36M+2.8%
-$201.64M+3.8%-$209.56M+1.9%-$213.64M-0.7%-$212.15M+1.0%-$214.36M-2.8%
$27.56M-53.8%$59.7M-7.7%$64.66M+1,112%$5.34M-1.7%$5.43M+806%
-$179.44M-15.6%-$155.22M-4.2%-$148.98M+28.0%-$206.81M+1.0%-$208.93M-0.5%
$0+100%-$15K-7.1%-$14K-450%$4K0.0%$4K-92.2%
-$179.44M-15.6%-$155.2M-4.2%-$148.97M+28.0%-$206.81M+1.0%-$208.93M-0.4%
-$2.12-7.1%-$1.98-33.8%-$1.48+45.0%-$2.69+12.1%-$3.06+3.8%
-$201.64M+3.8%-$209.56M+1.9%-$213.64M-0.7%-$212.15M+1.0%-$214.36M-2.8%

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Questions, answered.

Is Spyre Therapeutics, Inc. profitable?
Spyre Therapeutics, Inc. is not currently profitable: it reported a net loss of $179.4M over the trailing twelve months, a -52939.7% net margin.
What is Spyre Therapeutics, Inc.'s earnings per share?
Spyre Therapeutics, Inc.'s diluted EPS over the trailing twelve months is $-2.12.
Where does Spyre Therapeutics, Inc.'s income statement data come from?
Every line is extracted from Spyre Therapeutics, Inc.'s SEC filings (10-K and 10-Q) and tagged in XBRL. Switch between quarterly, annual, and trailing-twelve-month views, or open any line for its full history and peer comparisons.