What are Agios Pharmaceuticals's profit margins?

Agios Pharmaceuticals (AGIO) runs a 90.0% gross margin and a -720.0% operating margin, with a -639.8% net margin.

Where do Agios Pharmaceuticals's ratios come from?

Every ratio is computed from Agios Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

Agios Pharmaceuticals AGIO Ratios & Valuation

Income Statement Balance Sheet Cash Flow Ratios Segments

Quarterly Annual TTM

YoY QoQ

Simplified Detailed

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Profitability
Gross margin	90%+1.8pp	88.3%+1.0pp	87.2%-1.0pp	88.2%+0.7pp	87.5%-1.1pp
Operating margin	-720%+154pp	-873.9%+188pp	-1,061.8%+67.3pp	-1,129.1%+59.7pp	-1,188.9%-22.4pp
Net margin	-639.8%+124pp	-764%—	——	——	——
Returns
Return on equity	-32.8%-2.6pp	-30.2%—	——	——	——
Return on invested capital	-38.5%-3.1pp	-35.4%+0.2pp	-35.6%+11.0pp	-46.7%-5.4pp	-41.3%-4.5pp
Efficiency
Asset turnover	0×0.0×	0×0.0×	0×0.0×	0×0.0×	0×0.0×
Liquidity
Current ratio	14.2×+2.7×	11.5×-2.4×	13.8×-0.7×	14.5×-4.0×	18.5×+6.6×
Leverage
Debt-to-equity	0×0.0×	0×0.0×	0×0.0×	0×0.0×	0×0.0×
Per Share
Book value per share	$18.87-8.3%	$20.58-6.8%	$22.09-6.6%	$23.64-7.4%	$25.52-4.1%
Valuation
Market capitalization	$1.98B+24.9%	$1.59B-31.9%	$2.33B+20.5%	$1.94B+15.3%	$1.68B-10.4%
Price / sales	30×+0.6×	29.4×-22.7×	52.1×+4.7×	47.4×+2.0×	45.3×-6.0×
Price / book	1.8×+0.5×	1.3×-0.5×	1.8×+0.4×	1.4×+0.3×	1.1×-0.1×

Chart any of these lines over time, or line them up against competitors.

Compare these in charts →

Ask your AI about Agios Pharmaceuticals.

Connect your AI assistant and get a quick read on the numbers, right in your chat.

Connect your AI

Claude

Questions, answered.

What are Agios Pharmaceuticals's profit margins?: Agios Pharmaceuticals (AGIO) runs a 90.0% gross margin and a -720.0% operating margin, with a -639.8% net margin.
Where do Agios Pharmaceuticals's ratios come from?: Every ratio is computed from Agios Pharmaceuticals's SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.