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Ionis Pharmaceuticals IONS Income Tax Reconciliation Foreign Income Tax Rate Differential

Income Tax Reconciliation Foreign Income Tax Rate Differential at other companies

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RBC BearingsRBC
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$2.5M+100%
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CSXCSX
$750K
Ionis Pharmaceuticals logo
Ionis PharmaceuticalsIONS
-$29.5K-887%
Kimberly-Clark logo
Kimberly-ClarkKMB
$10.75M-44.9%

Other financials

Income statement

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Revenue$267.9M-40.7%
Gross profit$265.2M-40.8%
Operating income-$102.3M-173%
Net income-$114.6M-193%
EPS (diluted)-$0.69-199%

Balance sheet

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Cash & equivalents$350.1M+17.7%
Total debt$262.5M-67.0%
Total equity$439.7M-30.4%
Total assets$3.0B+0.3%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$16.1M+30.7%
Free cash flow-$814.6M-399%

Valuation

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Market cap$9.46B+45.4%
Enterprise value$9.37B+33.8%
P/S10.8×+3.9×

Profitability

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Gross margin98.2%-0.7pp
Operating margin-68%-234pp
Net margin-64.7%-299pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-105.5%+336pp
Debt / equity0.6×-0.7×
Current ratio7.9×+5.0×

Where this comes from

Reported directly by Ionis Pharmaceuticals in its filing.

Tagged under the XBRL concept us-gaap:IncomeTaxReconciliationForeignIncomeTaxRateDifferential.

The source filing: Ionis Pharmaceuticals’s 10-K, filed February 26, 2026.

Filed
Feb 26, 2026, 4:25 PM EST
Fiscal year
FY2026
Accession
0000874015-26-000115
Pre-tax loss$(379,601)
Statutory rate(79,716)21.0%%
State and local income tax, net of federal income tax effect (a)353(0.1)%
Foreign tax effects(118)0.0%%
Effect of cross-border tax laws459(0.1)%
Changes in unrecognized tax benefits12,145(3.2)%
Changes in valuation allowances93,773(24.7)%
Tax credits:

Item 15. Exhibits and Financial Statement Schedules

FAQ

What is Ionis Pharmaceuticals's income tax reconciliation foreign income tax rate differential?
Ionis Pharmaceuticals (IONS) reported income tax reconciliation foreign income tax rate differential of -$29.5K in Q4 2025.
How has Ionis Pharmaceuticals's income tax reconciliation foreign income tax rate differential changed year-over-year?
Ionis Pharmaceuticals's income tax reconciliation foreign income tax rate differential decreased by 886.7% year-over-year, from $3.75K to -$29.5K.
What is the long-term trend for Ionis Pharmaceuticals's income tax reconciliation foreign income tax rate differential?
Over 2 years (2023 to 2025), Ionis Pharmaceuticals's income tax reconciliation foreign income tax rate differential has grown at a 131.6% compound annual growth rate (CAGR), from -$22K to -$118K.
What does income tax reconciliation foreign income tax rate differential mean?
This represents the net tax impact resulting from the difference between the U.S. federal statutory tax rate and the tax rates applicable in foreign jurisdictions where the company conducts business. It highlights the tax benefit or cost associated with international operations. This is critical for evaluating the tax efficiency of the company's global corporate structure.

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