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Ionis Pharmaceuticals IONS Return on invested capital

Return on invested capital at other companies

Eli Lilly logo
Eli LillyLLY
39.7%+10.3pp
Pfizer logo
PfizerPFE
6%
Arrowhead Research logo
Arrowhead ResearchARWR
-38.8%+135pp
Ultragenyx Pharmaceutical logo
Ultragenyx PharmaceuticalRARE
-475.4%+443pp
Stoke Therapeutics, Inc. logo
Stoke Therapeutics, Inc.STOK
-114.4%
Intellia Therapeutics logo
Intellia TherapeuticsNTLA
-62.8%+0.9pp

Other financials

Income statement

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Revenue$267.9M-40.7%
Gross profit$265.2M-40.8%
Operating income-$102.3M-173%
Net income-$114.6M-193%
EPS (diluted)-$0.69-199%

Balance sheet

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Cash & equivalents$350.1M+17.7%
Total debt$262.5M-67.0%
Total equity$439.7M-30.4%
Total assets$3.0B+0.3%

Cash flow

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Operating cash flow-$792.8M-426%
CapEx$16.1M+30.7%
Free cash flow-$814.6M-399%

Valuation

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Market cap$9.01B+38.9%
Enterprise value$8.92B+27.7%
P/S10.3×+3.4×

Profitability

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Gross margin98.2%-0.7pp
Operating margin-68%-234pp
Net margin-64.7%-299pp
FCF margin-77.4%+35.3pp

Returns & leverage

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Return on equity-105.5%+336pp
Debt / equity0.6×-0.7×
Current ratio7.9×+5.0×

Where this comes from

Calculated from Ionis Pharmaceuticals’s reported figures.

Based on trailing twelve months.

The source filing: Ionis Pharmaceuticals’s 10-Q, filed July 29, 2026. Open the filing →

Filed
Jul 29, 2026, 5:05 PM EDT
Fiscal quarter
Q2 FY2026
Calendar quarter
Q2 2026
Accession
0000874015-26-000251

FAQ

What is Ionis Pharmaceuticals's return on invested capital?
Ionis Pharmaceuticals (IONS) reported return on invested capital of -80.3% in Q2 2026.
How has Ionis Pharmaceuticals's return on invested capital changed year-over-year?
Ionis Pharmaceuticals's return on invested capital decreased by 97.2% year-over-year, from -40.7% to -80.3%.
What is the long-term trend for Ionis Pharmaceuticals's return on invested capital?
Over 3 years (2020 to 2025), Ionis Pharmaceuticals's return on invested capital has grown at a 5.8% compound annual growth rate (CAGR), from -20.4% to -24.2%.
What does return on invested capital mean?
Net operating profit after tax (operating income taxed at the effective rate) divided by average invested capital (debt plus equity minus cash). Measures the after-tax return on all capital put to work in the business, independent of capital structure.

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