Septerna, Inc. SEPN Ratios & Valuation
| TTM Q1 '26 | TTM Q4 '25 | TTM Q3 '25 | TTM Q2 '25 | TTM Q1 '25 | ||
|---|---|---|---|---|---|---|
| Profitability | ||||||
| Operating margin | -77.1%+9,262pp | -148.6%— | -349.2%— | -14,071.1%— | -9,339.1%— | |
| Net margin | -49.9%+8,054pp | -106.4%— | -266.8%— | -12,053%— | -8,104.1%— | |
| EBITDA margin | -74.8%— | -145.1%— | -342%— | -13,857%— | —— | |
| Liquidity | ||||||
| Current ratio | 4.7×— | 4.7×— | 6.5×— | 22.1×— | —— | |
| Quick ratio | 4.7×— | 4.7×— | 6.5×— | 22.1×— | —— | |
| Cash ratio | 0.9×— | 1.4×— | 4.3×— | 12.5×— | —— | |
| Leverage | ||||||
| Debt-to-equity | 0.1×— | —— | —— | —— | —— | |
| Debt-to-assets | 0×— | 0×— | 0×— | 0.1×— | —— | |
| Per Share | ||||||
| Book value per share | $8.46+193% | $8.63-79.7% | $8.52+124% | $8.55+129% | -$9.11— | |
| Valuation | ||||||
| Market capitalization | $1.08B— | $1.25B— | $838.65M— | —— | —— | |
| Enterprise value | $1.03B— | $1.15B— | $542.77M— | —— | —— | |
| Price / sales | 14.9×— | 27.2×— | 38×— | —— | —— | |
| Price / book | 2.9×— | —— | —— | —— | —— | |
| EV / sales | 14.3×— | 25.1×— | 24.6×— | —— | —— | |
| Earnings yield | -3.3%— | -3.9%— | -7%— | —— | —— |
Chart any of these lines over time, or line them up against competitors.
Compare these in charts →Questions, answered.
- Where do Septerna, Inc.'s ratios come from?
- Every ratio is computed from Septerna, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.