What is Septerna, Inc.'s EBITDA margin?

Septerna, Inc. (SEPN) reported EBITDA margin of -74.8% in Q1 2026.

How has Septerna, Inc.'s EBITDA margin changed year-over-year?

Septerna, Inc.'s EBITDA margin increased by 99.2% year-over-year, from -9,187.4% to -74.8%.

What does EBITDA margin mean?

EBITDA (earnings before interest, taxes, depreciation, and amortization) as a percentage of revenue, trailing twelve months. A proxy for cash operating profitability that strips out capital-structure and non-cash charges.

Septerna, Inc. SEPN EBITDA margin

EBITDA margin at other companies

AmgenAMGN

41.5%+3.4pp

Stoke Therapeutics, Inc.STOK

-572.1%-593pp

Nurix Therapeutics, Inc.NRIX

-427.3%+42.6pp

Fortrea Holdings Inc.FTRE

-10.2%-3.5pp

PrecigenPGEN

-2,807.8%—

Catalyst PharmaceuticalCPRX

51.2%+0.9pp

Other financials

Income statement

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Revenue$26.5M+12,011%

Operating income-$13.3M+48.7%

Net income-$8.6M+59.8%

EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%

Total debt$23.1M-7.7%

Total equity$378.5M+195%

Total assets$569.7M+31.3%

Cash flow

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Operating cash flow-$25.6M-9.8%

CapEx$832.0K+118%

Free cash flow-$26.5M-11.5%

Valuation

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Market cap$1.65B+319%

Enterprise value$1.6B+1,325%

P/S22.8×-379×

Profitability

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Operating margin-77.1%-38.4pp

Net margin-49.9%-24.9pp

FCF margin467.9%+243pp

Returns & leverage

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Return on equity-12.2%—

Debt / equity0.1×—

Current ratio4.7×-27.5×

Where this comes from

Calculated from Septerna, Inc.’s reported figures.

ebitda/total revenue=-74.8%

Based on trailing twelve months.

The official record: Septerna, Inc.’s 10-Q, filed May 11, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Septerna, Inc.'s EBITDA margin?: Septerna, Inc. (SEPN) reported EBITDA margin of -74.8% in Q1 2026.
How has Septerna, Inc.'s EBITDA margin changed year-over-year?: Septerna, Inc.'s EBITDA margin increased by 99.2% year-over-year, from -9,187.4% to -74.8%.
What does EBITDA margin mean?: EBITDA (earnings before interest, taxes, depreciation, and amortization) as a percentage of revenue, trailing twelve months. A proxy for cash operating profitability that strips out capital-structure and non-cash charges.