What is Septerna, Inc.'s EBITDA?

Septerna, Inc. (SEPN) reported EBITDA of -$12.88M in Q1 2026.

How has Septerna, Inc.'s EBITDA changed year-over-year?

Septerna, Inc.'s EBITDA increased by 49.5% year-over-year, from -$25.51M to -$12.88M.

What does EBITDA mean?

Earnings before interest, taxes, depreciation, and amortization — EBIT plus the D&A add-back from the cash-flow statement (EBITDA = EBIT + D&A). A proxy for cash earnings that strips out financing, tax, and non-cash charges.

Septerna, Inc. (SEPN) EBITDA — Quarterly & Annual

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Other financials

Income statement

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Revenue$26.5M+12,011%

Operating income-$13.3M+48.7%

Net income-$8.6M+59.8%

EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%

Total debt$23.1M-7.7%

Total equity$378.5M+195%

Total assets$569.7M+31.3%

Cash flow

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Operating cash flow-$25.6M-9.8%

CapEx$832.0K+118%

Free cash flow-$26.5M-11.5%

Valuation

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Market cap$1.78B+240%

Enterprise value$1.73B+383%

P/S24.7×-696×

Profitability

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Operating margin-77.1%-38.4pp

Net margin-49.9%-24.9pp

FCF margin467.9%+243pp

Returns & leverage

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Return on equity-12.2%—

Debt / equity0.1×—

Current ratio4.7×-27.5×

Where this comes from

Calculated from Septerna, Inc.’s reported figures.

−$13.3Mebit+

$421.0KDepreciation Depletion & Amortization

=-$12.88M

The source filing: Septerna, Inc.’s 10-Q, filed May 11, 2026. Open the filing →

Filed: May 11, 2026, 4:08 PM EDT
Fiscal quarter: Q1 FY2026
Calendar quarter: Q1 2026
Accession: 0001193125-26-216759

FAQ

What is Septerna, Inc.'s EBITDA?: Septerna, Inc. (SEPN) reported EBITDA of -$12.88M in Q1 2026.
How has Septerna, Inc.'s EBITDA changed year-over-year?: Septerna, Inc.'s EBITDA increased by 49.5% year-over-year, from -$25.51M to -$12.88M.
What does EBITDA mean?: Earnings before interest, taxes, depreciation, and amortization — EBIT plus the D&A add-back from the cash-flow statement (EBITDA = EBIT + D&A). A proxy for cash earnings that strips out financing, tax, and non-cash charges.

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Septerna, Inc. SEPN EBITDA

EBITDA at other companies

Other financials

Income statement

Balance sheet

Cash flow

Valuation

Profitability

Returns & leverage

Where this comes from

FAQ

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