What is Septerna, Inc.'s EBIT?

Septerna, Inc. (SEPN) reported EBIT of -$13.3M in Q1 2026.

How has Septerna, Inc.'s EBIT changed year-over-year?

Septerna, Inc.'s EBIT increased by 48.7% year-over-year, from -$25.91M to -$13.3M.

Earnings before interest and taxes — the profit from the business before financing cost and tax. Uses reported operating income where a company reports it; otherwise pre-tax income plus interest expense. Lets companies be compared on earning power independent of capital structure.

Septerna, Inc. SEPN EBIT

EBIT at other companies

Stoke Therapeutics, Inc.STOK

-$53.42M-148%

Nurix Therapeutics, Inc.NRIX

-$92.5M-47.1%

Rapport Therapeutics, Inc.RAPP

-$24.22M+10.7%

Fortrea Holdings Inc.FTRE

-$3.4M+99.3%

PrecigenPGEN

-$5.99M+73.5%

AmgenAMGN

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Other financials

Income statement

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Revenue$26.5M+12,011%

Operating income-$13.3M+48.7%

Net income-$8.6M+59.8%

EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%

Total debt$23.1M-7.7%

Total equity$378.5M+195%

Total assets$569.7M+31.3%

Cash flow

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Operating cash flow-$25.6M-9.8%

CapEx$832.0K+118%

Free cash flow-$26.5M-11.5%

Valuation

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Market cap$1.65B+319%

Enterprise value$1.6B+1,325%

P/S22.8×-379×

Profitability

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Operating margin-77.1%-38.4pp

Net margin-49.9%-24.9pp

FCF margin467.9%+243pp

Returns & leverage

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Return on equity-12.2%—

Debt / equity0.1×—

Current ratio4.7×-27.5×

Where this comes from

Calculated from Septerna, Inc.’s reported figures.

−$13.3Moperating income−$8.3Mincome before tax=-$13.3M

Plus components not separately reported this period.

The official record: Septerna, Inc.’s 10-Q, filed May 11, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Septerna, Inc.'s EBIT?: Septerna, Inc. (SEPN) reported EBIT of -$13.3M in Q1 2026.
How has Septerna, Inc.'s EBIT changed year-over-year?: Septerna, Inc.'s EBIT increased by 48.7% year-over-year, from -$25.91M to -$13.3M.
What does EBIT mean?: Earnings before interest and taxes — the profit from the business before financing cost and tax. Uses reported operating income where a company reports it; otherwise pre-tax income plus interest expense. Lets companies be compared on earning power independent of capital structure.