What is Septerna, Inc.'s earnings yield?

Septerna, Inc. (SEPN) reported earnings yield of -3.3% in Q1 2026.

How has Septerna, Inc.'s earnings yield changed year-over-year?

Septerna, Inc.'s earnings yield increased by 89.1% year-over-year, from -30.8% to -3.3%.

What does earnings yield mean?

Trailing-twelve-month net income divided by market capitalization at the quarter end — the inverse of the P/E ratio, expressed as a percentage.

Septerna, Inc. SEPN Earnings yield

Earnings yield at other companies

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4.1%+0.6pp

Stoke Therapeutics, Inc.STOK

-8.8%-22.8pp

Nurix Therapeutics, Inc.NRIX

-18%+0.2pp

Rapport Therapeutics, Inc.RAPP

-7.2%-2.9pp

Maze Therapeutics, Inc. Common StockMAZE

-8.3%—

Fortrea Holdings Inc.FTRE

-50.7%-18.3pp

Other financials

Income statement

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Revenue$26.5M+12,011%

Operating income-$13.3M+48.7%

Net income-$8.6M+59.8%

EPS (diluted)-$0.19+61.2%

Balance sheet

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Cash & equivalents$71.6M-65.9%

Total debt$23.1M-7.7%

Total equity$378.5M+195%

Total assets$569.7M+31.3%

Cash flow

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Operating cash flow-$25.6M-9.8%

CapEx$832.0K+118%

Free cash flow-$26.5M-11.5%

Valuation

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Market cap$1.62B+319%

Profitability

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Operating margin-77.1%-38.4pp

Net margin-49.9%-24.9pp

FCF margin467.9%+243pp

Returns & leverage

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Return on equity-12.2%—

Debt / equity0.1×—

Current ratio4.7×-27.5×

Where this comes from

Calculated from Septerna, Inc.’s reported figures.

net income/market cap=-3.3%

Based on trailing twelve months.

The official record: Septerna, Inc.’s 10-Q, filed May 11, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Septerna, Inc.'s earnings yield?: Septerna, Inc. (SEPN) reported earnings yield of -3.3% in Q1 2026.
How has Septerna, Inc.'s earnings yield changed year-over-year?: Septerna, Inc.'s earnings yield increased by 89.1% year-over-year, from -30.8% to -3.3%.
What does earnings yield mean?: Trailing-twelve-month net income divided by market capitalization at the quarter end — the inverse of the P/E ratio, expressed as a percentage.