Septerna, Inc. SEPN Ratios & Valuation
| Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | ||
|---|---|---|---|---|---|---|
| Profitability | ||||||
| Operating margin | -77.1%+9,262pp | -148.6%+7,370pp | -349.2%+1,872pp | -14,071.1%-12,725pp | -9,339.1%— | |
| Net margin | -49.9%+8,054pp | -106.4%+6,573pp | -266.8%+1,388pp | -12,053%-11,259pp | -8,104.1%— | |
| EBITDA margin | -74.8%+9,113pp | -145.1%+7,243pp | -342%+1,751pp | -13,857%— | -9,187.4%— | |
| Returns | ||||||
| Return on assets | -7.2%— | -9.3%+15.2pp | -15.1%— | —— | —— | |
| Efficiency | ||||||
| Asset turnover | 0.1×— | 0.1×+0.1× | 0.1×— | —— | —— | |
| Liquidity | ||||||
| Current ratio | 4.7×-27.5× | 4.7×-23.0× | 6.5×-3.6× | 22.1×— | 32.2×— | |
| Quick ratio | 4.7×-27.5× | 4.7×-23.0× | 6.5×-3.6× | 22.1×— | 32.2×— | |
| Cash ratio | 0.9×-18.8× | 1.4×-17.1× | 4.3×-2.4× | 12.5×— | 19.7×— | |
| Leverage | ||||||
| Debt-to-equity | 0.1×— | 0.1×0.0× | 0.1×— | 0.1×— | —— | |
| Debt-to-assets | 0×0.0× | 0×0.0× | 0×-0.1× | 0.1×— | 0.1×— | |
| Per Share | ||||||
| Book value per share | $8.46+193% | $8.63-79.7% | $8.52+124% | $8.55+129% | -$9.11+60.8% | |
| Valuation | ||||||
| Market capitalization | $1.08B+319% | $1.25B+22.8% | $838.65M— | $477.22M— | $257.32M— | |
| Enterprise value | $1.03B+1,325% | $1.15B+43.2% | $542.77M— | $312.48M— | $72.3M— | |
| Price / sales | 14.9×-248× | 27.2×-919× | 38×— | 657.3×— | 263.4×— | |
| Price / book | 2.9×— | 3.3×+0.8× | 2.2×— | 1.3×— | —— | |
| EV / sales | 14.3×-59.7× | 25.1×-723× | 24.6×— | 430.4×— | 74×— | |
| Earnings yield | -3.3%+27.4pp | -3.9%+3.1pp | -7%— | -18.3%— | -30.8%— |
Chart any of these lines over time, or line them up against competitors.
Compare these in charts →Questions, answered.
- Where do Septerna, Inc.'s ratios come from?
- Every ratio is computed from Septerna, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.
