What is Prime Medicine's earnings yield?

Prime Medicine (PRME) reported earnings yield of -31.6% in Q1 2026.

How has Prime Medicine's earnings yield changed year-over-year?

Prime Medicine's earnings yield increased by 59.2% year-over-year, from -77.4% to -31.6%.

What is the long-term trend for Prime Medicine's earnings yield?

Over 3 years (2022 to 2025), Prime Medicine's earnings yield has grown at a 53.7% compound annual growth rate (CAGR), from -8.8% to -32.1%.

What does earnings yield mean?

Trailing-twelve-month net income divided by market capitalization at the quarter end — the inverse of the P/E ratio, expressed as a percentage.

Prime Medicine PRME Earnings yield

Earnings yield at other companies

Eli LillyLLY

3.1%+1.6pp

Vertex PharmaceuticalsVRTX

3.8%—

Intellia TherapeuticsNTLA

-26.1%-10.1pp

CRISPR TherapeuticsCRSP

-12.5%-0.7pp

Beam TherapeuticsBEAM

-16.9%—

RegenxbioRGNX

-67.1%+73.5pp

Other financials

Income statement

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Revenue$838.0K-61.6%

Operating income-$50.7M+3.3%

Net income-$49.1M+5.3%

EPS (diluted)-$0.28+30.0%

Balance sheet

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Cash & equivalents$77.8M-26.6%

Total debt$114.5M-5.5%

Total equity$76.7M-28.3%

Total assets$294.7M-10.2%

Cash flow

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Operating cash flow-$42.7M+12.6%

CapEx$214.0K-91.2%

Free cash flow-$42.9M+16.3%

Valuation

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Market cap$574.36M+111%

Enterprise value$611.08M+113%

P/S124×+6.3×

Profitability

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Operating margin-4,498.1%-1,134pp

Net margin-4,342.4%-1,099pp

FCF margin-3,607.4%—

Returns & leverage

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Return on equity-216.1%+1,519pp

Debt / equity1.5×+0.4×

Current ratio3.8×-1.0×

Where this comes from

Calculated from Prime Medicine’s reported figures.

net income/market cap=-31.6%

Based on trailing twelve months.

The official record: Prime Medicine’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Prime Medicine's earnings yield?: Prime Medicine (PRME) reported earnings yield of -31.6% in Q1 2026.
How has Prime Medicine's earnings yield changed year-over-year?: Prime Medicine's earnings yield increased by 59.2% year-over-year, from -77.4% to -31.6%.
What is the long-term trend for Prime Medicine's earnings yield?: Over 3 years (2022 to 2025), Prime Medicine's earnings yield has grown at a 53.7% compound annual growth rate (CAGR), from -8.8% to -32.1%.
What does earnings yield mean?: Trailing-twelve-month net income divided by market capitalization at the quarter end — the inverse of the P/E ratio, expressed as a percentage.