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Prime Medicine PRME EBITDA margin

EBITDA margin at other companies

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40.1%+36.9pp
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-622.2%-198pp
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-15,289.6%-16,725pp
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-212.9%-85.3pp
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-274.6%-538pp

Other financials

Income statement

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Revenue$838.0K-61.6%
Operating income-$50.7M+3.3%
Net income-$49.1M+5.3%
EPS (diluted)-$0.28+30.0%

Balance sheet

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Cash & equivalents$77.8M-26.6%
Total debt$114.5M-5.5%
Total equity$76.7M-28.3%
Total assets$294.7M-10.2%

Cash flow

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Operating cash flow-$42.7M+12.6%
CapEx$214.0K-91.2%
Free cash flow-$42.9M+16.3%

Valuation

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Market cap$574.36M+111%
Enterprise value$611.08M+113%
P/S124×+6.3×

Profitability

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Operating margin-4,498.1%-1,134pp
Net margin-4,342.4%-1,099pp
FCF margin-3,607.4%

Returns & leverage

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Return on equity-216.1%+1,519pp
Debt / equity1.5×+0.4×
Current ratio3.8×-1.0×

Where this comes from

Calculated from Prime Medicine’s reported figures.

Based on trailing twelve months.

The official record: Prime Medicine’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Prime Medicine's EBITDA margin?
Prime Medicine (PRME) reported EBITDA margin of -4,340% in Q4 2025.
How has Prime Medicine's EBITDA margin changed year-over-year?
Prime Medicine's EBITDA margin increased by 34.1% year-over-year, from -6,581.9% to -4,340%.
What is the long-term trend for Prime Medicine's EBITDA margin?
Over 2 years (2020 to 2025), Prime Medicine's EBITDA margin has grown at a 1494.8% compound annual growth rate (CAGR), from -17.1% to -4,340%.
What does EBITDA margin mean?
EBITDA (earnings before interest, taxes, depreciation, and amortization) as a percentage of revenue, trailing twelve months. A proxy for cash operating profitability that strips out capital-structure and non-cash charges.