What is Prime Medicine's EV / sales?

Prime Medicine (PRME) reported EV / sales of 143.8× in Q4 2025.

How has Prime Medicine's EV / sales changed year-over-year?

Prime Medicine's EV / sales increased by 88.8% year-over-year, from 76.2× to 143.8×.

What does EV / sales mean?

Enterprise value at the quarter end divided by trailing-twelve-month revenue. A capital-structure-neutral revenue multiple, useful when earnings are negative.

Prime Medicine PRME EV / sales

EV / sales at other companies

Eli LillyLLY

11.9×-4.0×

Vertex PharmaceuticalsVRTX

9×-1.9×

Intellia TherapeuticsNTLA

22.1×+6.1×

CRISPR TherapeuticsCRSP

1,201.6×+1,125×

Beam TherapeuticsBEAM

14.6×-10.3×

RegenxbioRGNX

5.6×+3.6×

Other financials

Income statement

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Revenue$838.0K-61.6%

Operating income-$50.7M+3.3%

Net income-$49.1M+5.3%

EPS (diluted)-$0.28+30.0%

Balance sheet

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Cash & equivalents$77.8M-26.6%

Total debt$114.5M-5.5%

Total equity$76.7M-28.3%

Total assets$294.7M-10.2%

Cash flow

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Operating cash flow-$42.7M+12.6%

CapEx$214.0K-91.2%

Free cash flow-$42.9M+16.3%

Valuation

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Market cap$574.36M+111%

Enterprise value$611.08M+113%

P/S124×+6.3×

Profitability

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Operating margin-4,498.1%-1,134pp

Net margin-4,342.4%-1,099pp

FCF margin-3,607.4%—

Returns & leverage

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Return on equity-216.1%+1,519pp

Debt / equity1.5×+0.4×

Current ratio3.8×-1.0×

Where this comes from

Calculated from Prime Medicine’s reported figures.

enterprise value/total revenue=143.8×

Based on the most recent quarter.

The official record: Prime Medicine’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Prime Medicine's EV / sales?: Prime Medicine (PRME) reported EV / sales of 143.8× in Q4 2025.
How has Prime Medicine's EV / sales changed year-over-year?: Prime Medicine's EV / sales increased by 88.8% year-over-year, from 76.2× to 143.8×.
What does EV / sales mean?: Enterprise value at the quarter end divided by trailing-twelve-month revenue. A capital-structure-neutral revenue multiple, useful when earnings are negative.