What is Prime Medicine's free cash flow yield?

Prime Medicine (PRME) reported free cash flow yield of -25.3% in Q1 2026.

What is the long-term trend for Prime Medicine's free cash flow yield?

Over 2 years (2022 to 2025), Prime Medicine's free cash flow yield has grown at a 57.7% compound annual growth rate (CAGR), from -10.7% to -26.7%.

What does free cash flow yield mean?

Trailing-twelve-month free cash flow divided by market capitalization at the quarter end. The cash return the business generates relative to its market price.

Prime Medicine PRME Free cash flow yield

Free cash flow yield at other companies

Eli LillyLLY

1.4%+0.9pp

Vertex PharmaceuticalsVRTX

3.3%+2.2pp

Intellia TherapeuticsNTLA

-24%-8.4pp

CRISPR TherapeuticsCRSP

-8.8%-1.3pp

Beam TherapeuticsBEAM

-15.8%-2.0pp

RegenxbioRGNX

-54.7%-272pp

Other financials

Income statement

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Revenue$838.0K-61.6%

Operating income-$50.7M+3.3%

Net income-$49.1M+5.3%

EPS (diluted)-$0.28+30.0%

Balance sheet

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Cash & equivalents$77.8M-26.6%

Total debt$114.5M-5.5%

Total equity$76.7M-28.3%

Total assets$294.7M-10.2%

Cash flow

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Operating cash flow-$42.7M+12.6%

CapEx$214.0K-91.2%

Free cash flow-$42.9M+16.3%

Valuation

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Market cap$574.36M+111%

Enterprise value$611.08M+113%

P/S124×+6.3×

Profitability

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Operating margin-4,498.1%-1,134pp

Net margin-4,342.4%-1,099pp

FCF margin-3,607.4%—

Returns & leverage

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Return on equity-216.1%+1,519pp

Debt / equity1.5×+0.4×

Current ratio3.8×-1.0×

Where this comes from

Calculated from Prime Medicine’s reported figures.

free cash flow/market cap=-25.3%

Based on trailing twelve months.

The official record: Prime Medicine’s 10-Q, filed May 7, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Prime Medicine's free cash flow yield?: Prime Medicine (PRME) reported free cash flow yield of -25.3% in Q1 2026.
What is the long-term trend for Prime Medicine's free cash flow yield?: Over 2 years (2022 to 2025), Prime Medicine's free cash flow yield has grown at a 57.7% compound annual growth rate (CAGR), from -10.7% to -26.7%.
What does free cash flow yield mean?: Trailing-twelve-month free cash flow divided by market capitalization at the quarter end. The cash return the business generates relative to its market price.