Where do Spyre Therapeutics, Inc.'s ratios come from?

Every ratio is computed from Spyre Therapeutics, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

	Q1 '26	Q4 '25	Q3 '25	Q2 '25	Q1 '25
Returns
Return on equity	-31.1%-5.9pp	-25.2%+12.9pp	-38.1%+11.7pp	-49.8%+16.0pp	-65.8%-6.5pp
Return on assets	-26.9%-4.5pp	-22.4%+9.8pp	-32.2%+10.2pp	-42.4%-2.9pp	-39.5%+4.3pp
Liquidity
Current ratio	9×-4.3×	13.3×+2.3×	10.9×+4.4×	6.5×-1.6×	8.1×-3.2×
Quick ratio	9×-4.3×	13.3×+2.3×	10.9×+4.4×	6.5×-1.6×	8.1×-3.2×
Cash ratio	1.1×-0.3×	1.5×+0.1×	1.4×+0.4×	1×+0.3×	0.7×-1.0×
Per Share
Book value per share	$8.54-23.5%	$11.17+48.2%	$7.53-0.3%	$7.55-5.7%	$8.01-27.3%
Valuation
Market capitalization	$3.96B+55.8%	$2.54B+151%	$1.01B+8.8%	$930.05M-4.3%	$972.25M-30.2%
Price / book	5.9×+2.4×	3.6×+1.3×	2.2×+0.2×	2×0.0×	2×-0.7×
Earnings yield	-4.5%+1.6pp	-6.1%+8.6pp	-14.7%+7.5pp	-22.2%-0.7pp	-21.5%-6.5pp

Chart any of these lines over time, or line them up against competitors.

Compare these in charts →

Questions, answered.

Where do Spyre Therapeutics, Inc.'s ratios come from?: Every ratio is computed from Spyre Therapeutics, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.