What is Spyre Therapeutics, Inc.'s book value per share?

Spyre Therapeutics, Inc. (SYRE) reported book value per share of $8.54 in Q1 2026.

How has Spyre Therapeutics, Inc.'s book value per share changed year-over-year?

Spyre Therapeutics, Inc.'s book value per share increased by 6.6% year-over-year, from $8.01 to $8.54.

What is the long-term trend for Spyre Therapeutics, Inc.'s book value per share?

Over 5 years (2020 to 2025), Spyre Therapeutics, Inc.'s book value per share has grown at a 33.6% compound annual growth rate (CAGR), from $2.62 to $11.17.

Spyre Therapeutics, Inc. SYRE Book value per share

Book value per share at other companies

Eli LillyLLY

$34.82+98.9%

PfizerPFE

$15.72-0.6%

Johnson & JohnsonJNJ

$33.20+3.0%

AbbVieABBV

-$3.75-568%

TG TherapeuticsTGTX

$3.64+150%

BridgeBio PharmaBBIO

-$11.70-34.9%

Other financials

Income statement

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Revenue-—

Operating income-$45.6M+14.8%

Net income-$69.0M-54.1%

EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%

Total debt$4.3M-9.6%

Total equity$670.8M+39.0%

Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%

CapEx-—

Free cash flow-$39.4M-26.8%

Valuation

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Market cap$7.67B+307%

Profitability

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Operating margin-39,428.9%-49,795pp

Net margin-52,939.7%-61,871pp

FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp

Debt / equity0.1×+0.1×

Current ratio9×+0.9×

Where this comes from

Calculated from Spyre Therapeutics, Inc.’s reported figures.

total stockholders equity/weighted shares diluted=$8.54

Based on the most recent quarter.

The official record: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s book value per share?: Spyre Therapeutics, Inc. (SYRE) reported book value per share of $8.54 in Q1 2026.
How has Spyre Therapeutics, Inc.'s book value per share changed year-over-year?: Spyre Therapeutics, Inc.'s book value per share increased by 6.6% year-over-year, from $8.01 to $8.54.
What is the long-term trend for Spyre Therapeutics, Inc.'s book value per share?: Over 5 years (2020 to 2025), Spyre Therapeutics, Inc.'s book value per share has grown at a 33.6% compound annual growth rate (CAGR), from $2.62 to $11.17.