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Return on assets at other companies

Bristol-Myers Squibb logo
Bristol-Myers SquibbBMY
8.1%+2.5pp
Eli Lilly logo
Eli LillyLLY
24.5%+10.1pp
Pfizer logo
PfizerPFE
4.6%
Johnson & Johnson logo
Johnson & JohnsonJNJ
10.7%-1.3pp
Merck & Co. logo
Merck & Co.MRK
7.3%-8.4pp
AbbVie logo
AbbVieABBV
2.7%-0.3pp

Other financials

Income statement

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Revenue-
Operating income-$45.6M+14.8%
Net income-$69.0M-54.1%
EPS (diluted)-$0.74-23.3%

Balance sheet

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Cash & equivalents$97.2M+100%
Total debt$4.3M-9.6%
Total equity$670.8M+39.0%
Total assets$764.0M+34.1%

Cash flow

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Operating cash flow-$57.4M-40.0%
CapEx-
Free cash flow-$39.4M-26.8%

Valuation

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Market cap$7.67B+307%

Profitability

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Operating margin-39,428.9%-49,795pp
Net margin-52,939.7%-61,871pp
FCF margin-3,442.8%-3,807pp

Returns & leverage

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Return on equity-31.1%-10.7pp
Debt / equity0.1×+0.1×
Current ratio+0.9×

Where this comes from

Calculated from Spyre Therapeutics, Inc.’s reported figures.

Based on trailing twelve months.

The official record: Spyre Therapeutics, Inc.’s 10-Q, filed May 5, 2026, on SEC EDGAR. View the filing →

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Questions, answered.

What is Spyre Therapeutics, Inc.'s return on assets?
Spyre Therapeutics, Inc. (SYRE) reported return on assets of -26.9% in Q1 2026.
How has Spyre Therapeutics, Inc.'s return on assets changed year-over-year?
Spyre Therapeutics, Inc.'s return on assets increased by 31.9% year-over-year, from -39.5% to -26.9%.
What is the long-term trend for Spyre Therapeutics, Inc.'s return on assets?
Over 5 years (2020 to 2025), Spyre Therapeutics, Inc.'s return on assets has grown at a -19.5% compound annual growth rate (CAGR), from -66.1% to -22.4%.
What does return on assets mean?
Trailing-twelve-month net income divided by average total assets. Measures how efficiently the asset base generates profit, independent of how those assets are financed. Computed as net income over average total assets — note this is OpenCapital's standard definition and may differ from data vendors that use alternative numerators.