Where do Spyre Therapeutics, Inc.'s ratios come from?

Every ratio is computed from Spyre Therapeutics, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.

	TTM Q1 '26	TTM Q4 '25	TTM Q3 '25	TTM Q2 '25	TTM Q1 '25
Returns
Return on equity	-31.1%—	-25.2%—	-38.1%—	——	——
Return on assets	-26.9%+12.6pp	-22.4%+21.4pp	-32.2%+36.2pp	-42.4%+12.3pp	-39.5%+95.4pp
Liquidity
Current ratio	9×+0.9×	13.3×+2.0×	10.9×+3.6×	6.5×-13.2×	8.1×-3.3×
Quick ratio	9×+0.9×	13.3×+2.0×	10.9×+3.6×	6.5×-13.2×	8.1×-3.3×
Cash ratio	1.1×+0.5×	1.5×-0.2×	1.4×+0.2×	1×-1.1×	0.7×-4.6×
Per Share
Book value per share	$8.54+6.6%	$11.17+1.4%	$7.53+17.1%	$7.55-8.6%	$8.01+92.0%
Valuation
Market capitalization	$3.96B+307%	$2.54B+82.6%	$1.01B-32.4%	$930.05M-22.1%	$972.25M-29.1%
Price / book	5.9×+3.9×	3.6×+0.9×	2.2×-2.3×	2×—	2×—
Earnings yield	-4.5%+17.0pp	-6.1%+8.8pp	-14.7%-0.4pp	-22.2%-6.7pp	-21.5%+5.1pp

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Questions, answered.

Where do Spyre Therapeutics, Inc.'s ratios come from?: Every ratio is computed from Spyre Therapeutics, Inc.'s SEC filings — trailing-twelve-month flows over period-end balances. Valuation multiples combine those fundamentals with market data, recomputed each period. Switch between quarterly, annual, and TTM, or open any ratio for its full history and peer comparisons.